Childhood adiposity and risk of type 1 diabetes: A Mendelian randomization study

The incidence of type 1 diabetes (T1D) is increasing globally. One hypothesis is that increasing childhood obesity rates may explain part of this increase, but, as T1D is rare, intervention studies are challenging to perform. The aim of this study was to assess this hypothesis with a Mendelian rando...

Full description

Bibliographic Details

Published in:	PLoS medicine 2017-08, Vol.14 (8), p.e1002362-e1002362
Main Authors:	Censin, J C, Nowak, Christoph, Cooper, Nicholas, Bergsten, Peter, Todd, John A, Fall, Tove
Format:	Article
Language:	eng
Subjects:	Adipose tissue Adiposity Analysis Anthropometry Bias Biology and Life Sciences Body mass Body mass index Child Child, Preschool Childhood obesity Children Diabetes in children Diabetes mellitus Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - etiology Diabetes Mellitus, Type 1 - genetics Dilution Epidemics Europe - epidemiology Female Genetic aspects Genetics Genome-wide association studies Genome-Wide Association Study Genomes Health risk assessment Health risks Humans Intervention Juvenile diabetes Male Medicine and Health Sciences Mendelian Randomization Analysis Multivariable control Nuclear electric power generation Obesity Obesity in children Odds Ratio Pediatric Obesity - complications Pediatric Obesity - epidemiology Pediatric Obesity - genetics Physical Sciences Pleiotropy Polymorphism, Single Nucleotide Randomization Risk Risk Factors Rodents Sensitivity analysis Single nucleotide polymorphisms Single-nucleotide polymorphism Social Sciences Studies Test procedures Tobacco Variance analysis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!