Resveratrol improves alcoholic fatty liver disease by downregulating HIF-1α expression and mitochondrial ROS production

Oxidative stress has been demonstrated to be involved in the etiology of alcoholic fatty liver disease (AFLD). Previous studies had demonstrated that resveratrol (RES) could reduce oxidative stress by different mechanisms. However, the effect of RES on alcohol-induced fatty liver remains unclear. In...

Full description

Saved in:

Bibliographic Details
Published in:	PloS one 2017-08, Vol.12 (8), p.e0183426-e0183426
Main Authors:	Ma, Zhenhua, Zhang, Yangmin, Li, Qingchun, Xu, Meng, Bai, Jigang, Wu, Shengli
Format:	Article
Language:	eng
Subjects:	Alanine Transaminase - blood Alcohol Alcohol use Alcohols Animals Aspartate Aminotransferases - blood Biology and Life Sciences Biomarkers - blood Ethanol - blood Etiology Fatty liver Fatty Liver, Alcoholic - metabolism Fatty Liver, Alcoholic - prevention & control Hospitals Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Injury prevention Laboratory animals Liver Liver diseases Male Medicine and Health Sciences Mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Oxidative stress Oxygen Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Research and Analysis Methods Resveratrol Rodents Social Sciences Stilbenes - pharmacology Supplements Surgery
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Oxidative stress has been demonstrated to be involved in the etiology of alcoholic fatty liver disease (AFLD). Previous studies had demonstrated that resveratrol (RES) could reduce oxidative stress by different mechanisms. However, the effect of RES on alcohol-induced fatty liver remains unclear. In the present study, a total of 48 male SD rats were divided into three groups: Control, AFLD, and RES groups. Rats were administered with either nothing or 65% vol/vol alcohol (5 ml/kg/day in the first three days, and then 10 ml/kg/day in the following days) with or without RES supplementation (250 mg/kg/day) for 4 weeks. Blood and liver tissue samples were collected and subjected to biochemical assays, histological examination, Western blot, and mitochondrial radical oxygen species (ROS) assays. In RES group, significant decreases in serum ALT and AST concentrations, fat deposition, triglyceride (TG) content, HIF-1α protein expression as well as mitochondrial ROS production in liver were observed when compared with AFLD group (all p
ISSN:	1932-6203 1932-6203