Medication eluting devices for the field of OBGYN (MEDOBGYN): 3D printed biodegradable hormone eluting constructs, a proof of concept study

3D printing has the potential to deliver personalized implants and devices for obstetric and gynecologic applications. The aim of this study is to engineer customizable and biodegradable 3D printed implant materials that can elute estrogen and/or progesterone. All 3D constructs were printed using po...

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Bibliographic Details
Published in:PloS one 2017-08, Vol.12 (8), p.e0182929-e0182929
Main Authors: Tappa, Karthik, Jammalamadaka, Udayabhanu, Ballard, David H, Bruno, Todd, Israel, Marissa R, Vemula, Harika, Meacham, J Mark, Mills, David K, Woodard, Pamela K, Weisman, Jeffery A
Format: Article
Language:English
Subjects:
3-D printers
3D printing
Absorbable Implants
Anatomy
Antibiotics
Biocompatibility
Biocompatible Materials - chemistry
Biodegradability
Biodegradation
Biological activity
Biology and Life Sciences
Biomaterials
Biomedical engineering
Biomedical materials
Birth control
CAD
Calorimetry
Computer aided design
Customization
Degradation
Differential scanning calorimetry
Dosimetry
Drug delivery
Drug delivery systems
Drug Delivery Systems - instrumentation
Drug dosages
Drugs
Engineering
Engineering and technology
Enzyme-linked immunosorbent assay
Equipment Design
Estrogens
Estrogens - administration & dosage
Feasibility studies
Female
Gynecology
Heat measurement
Hormones
Humans
Innovations
Intrauterine devices
Intrauterine Devices, Medicated
IUD
Medical equipment
Medicine
Medicine and Health Sciences
Obstetrics
Pessaries
Physical Sciences
Polycaprolactone
Polyesters - chemistry
Precision medicine
Printing
Printing, Three-Dimensional
Progesterone
Progesterone - administration & dosage
Radiation therapy
Research and Analysis Methods
Rods
Surgery
Surgical implants
Surgical Mesh
Temperature effects
Thermal analysis
Thermal properties
Thermodynamic properties
Thermogravimetric analysis
Three dimensional printing
Transplants & implants
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Summary:3D printing has the potential to deliver personalized implants and devices for obstetric and gynecologic applications. The aim of this study is to engineer customizable and biodegradable 3D printed implant materials that can elute estrogen and/or progesterone. All 3D constructs were printed using polycaprolactone (PCL) biodegradable polymer laden with estrogen or progesterone and were subjected to hormone-release profile studies using ELISA kits. Material thermal properties were tested using thermogravimetric analysis and differential scanning calorimetry. The 3D printed constructs showed extended hormonal release over a one week period. Cytocompatibility and bioactivity were assessed using a luciferase assay. The hormone-laden 3D printed constructs demonstrated an increase in luciferase activity and without any deleterious effects. Thermal properties of the PCL and hormones showed degradation temperatures above that of the temperature used in the additive manufacturing process-suggesting that 3D printing can be achieved below the degradation temperatures of the hormones. Sample constructs in the shape of surgical meshes, subdermal rods, intrauterine devices and pessaries were designed and printed. 3D printing of estrogen and progesterone-eluting constructs was feasible in this proof of concept study. These custom designs have the potential to act as a form of personalized medicine for drug delivery and optimized fit based on patient-specific anatomy.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0182929