The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models

The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with B...

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Bibliographic Details
Published in:PloS one 2017-07, Vol.12 (7), p.e0181485-e0181485
Main Authors: Wolters, Maike, Dering, Carmen, Siani, Alfonso, Russo, Paola, Kaprio, Jaakko, Risé, Patrizia, Moreno, Luis A, De Henauw, Stefaan, Mehlig, Kirsten, Veidebaum, Toomas, Molnár, Denés, Tornaritis, Michael, Iacoviello, Licia, Pitsiladis, Yannis, Galli, Claudio, Foraita, Ronja, Börnhorst, Claudia
Format: Article
Language:English
Subjects:
Age
Alleles
Analysis
Arachidonic acid
Biology and Life Sciences
Blood
Blood levels
Blood pressure
Blood Pressure - genetics
Blood Pressure Determination
Body mass
Body Mass Index
Cardiovascular disease
Child
Child, Preschool
Children
Cholesterol
Chromatography, Gas
Cohort Studies
Consortia
Cross-Sectional Studies
Desaturase
Diet
Eicosapentaenoic acid
Enzymes
Epidemics
Epidemiology
Europe
Fatty Acid Desaturases - genetics
Fatty acids
Fatty Acids - blood
Female
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Gas chromatography
Genes
Genetic diversity
Genetic Predisposition to Disease
Genetics
Genotyping Techniques
Health aspects
Heterozygote
Humans
Hypertension
Identification methods
Independent variables
Infants
Linolenic acid
Male
Mathematical models
Medicine
Medicine and Health Sciences
Models, Theoretical
Obesity
Parents
Polymorphism
Polymorphism, Single Nucleotide
Polyunsaturated fatty acids
Population genetics
Prevention
Public Health, Global Health, Social Medicine and Epidemiology
Risk factors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
Teenagers
Triglycerides
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Summary:The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP. A subsample of the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) baseline survey including 520 children aged 2 to
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0181485