A system model of the effects of exercise on plasma Interleukin-6 dynamics in healthy individuals: Role of skeletal muscle and adipose tissue

Interleukin-6 (IL-6) has been recently shown to play a central role in glucose homeostasis, since it stimulates the production and secretion of Glucagon-like Peptide-1 (GLP-1) from intestinal L-cells and pancreas, leading to an enhanced insulin response. In resting conditions, IL-6 is mainly produce...

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Bibliographic Details
Published in:PloS one 2017-07, Vol.12 (7), p.e0181224-e0181224
Main Authors: Morettini, Micaela, Palumbo, Maria Concetta, Sacchetti, Massimo, Castiglione, Filippo, Mazzà, Claudia
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - metabolism
Biology and Life Sciences
Body fat
Calculus
Coefficient of variation
Computer simulation
Councils
Cytokines
Diabetes
Diabetes mellitus
Dynamics
Exercise
Exercise intensity
Glucagon
Glucagon-like peptide 1
Glucose
Health aspects
Homeostasis
Humans
Inflammation
Insulin
Insulin resistance
Insulin secretion
Integration
Interleukin
Interleukin 6
Interleukin-6 - blood
Intestine
Mathematical models
Medicine and Health Sciences
Metabolism
Metabolites
Models, Biological
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiology
Musculoskeletal system
Ordinary differential equations
Oxygen
Oxygen Consumption
Oxygen uptake
Pancreas
Parameter estimation
Physical Sciences
Physiological effects
Plasmas (physics)
Skeletal muscle
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Summary:Interleukin-6 (IL-6) has been recently shown to play a central role in glucose homeostasis, since it stimulates the production and secretion of Glucagon-like Peptide-1 (GLP-1) from intestinal L-cells and pancreas, leading to an enhanced insulin response. In resting conditions, IL-6 is mainly produced by the adipose tissue whereas, during exercise, skeletal muscle contractions stimulate a marked IL-6 secretion as well. Available mathematical models describing the effects of exercise on glucose homeostasis, however, do not account for this IL-6 contribution. This study aimed at developing and validating a system model of exercise's effects on plasma IL-6 dynamics in healthy humans, combining the contributions of both adipose tissue and skeletal muscle. A two-compartment description was adopted to model plasma IL-6 changes in response to oxygen uptake's variation during an exercise bout. The free parameters of the model were estimated by means of a cross-validation procedure performed on four different datasets. A low coefficient of variation (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0181224