A novel potential biomarker for metabolic syndrome in Chinese adults: Circulating protein disulfide isomerase family A, member 4

Protein disulfide isomerase (PDI) family members are specific endoplasmic reticulum proteins that are involved in the pathogenesis of numerous diseases including neurodegenerative diseases, cancer and obesity. However, the metabolic effects of PDIA4 remain unclear in humans. The aims of this study w...

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Bibliographic Details
Published in:PloS one 2017-06, Vol.12 (6), p.e0179963-e0179963
Main Authors: Chien, Chu-Yen, Hung, Yi-Jen, Shieh, Yi-Shing, Hsieh, Chang-Hsun, Lu, Chieh-Hua, Lin, Fu-Huang, Su, Sheng-Chiang, Lee, Chien-Hsing
Format: Article
Language:English
Subjects:
Adult
Adults
Apolipoproteins
Asian Continental Ancestry Group
Biochemistry
Biomarkers - blood
Blood
Blood pressure
Cancer
Case-Control Studies
Cholesterol
Cross-Sectional Studies
Diabetes
Diagnostic systems
Dyslipidemias
Education
Endocrinology
Endoplasmic reticulum
Endoplasmic Reticulum - enzymology
Endoplasmic Reticulum Stress
Fasting
Female
Glucose
Health aspects
Health risks
Heart attacks
Homeostasis
Hospitals
Humans
Insulin
Insulin resistance
Isomerases
Kinases
Lipids
Male
Men
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - enzymology
Metabolic Syndrome - etiology
Metabolic syndrome X
Middle Aged
Mutation
Neurodegenerative diseases
Neurological diseases
Obesity
Pathogenesis
Patients
Physiology
Protein disulfide-isomerase
Protein Disulfide-Isomerases - blood
Protein folding
Proteins
Public health
Risk Factors
Sensitivity
Sensitivity analysis
Studies
Taiwan
Triglycerides
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Summary:Protein disulfide isomerase (PDI) family members are specific endoplasmic reticulum proteins that are involved in the pathogenesis of numerous diseases including neurodegenerative diseases, cancer and obesity. However, the metabolic effects of PDIA4 remain unclear in humans. The aims of this study were to investigate the associations of serum PDIA4 with the metabolic syndrome (MetS) and its components in Chinese adults. A total of 669 adults (399 men and 270 women) were recruited. Serum PDIA4 concentrations and biochemical variables were recorded. Insulin sensitivity and β-cell function were examined by homeostasis model assessment. MetS was defined based on the modified National Cholesterol Education Program Adult Treatment Panel III criteria for Asia Pacific. The participants with MetS had significantly higher serum PDIA4 levels than those without MetS (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0179963