Genetic variations in sterol regulatory element binding protein cleavage-activating protein (SCAP) are associated with blood pressure in overweight/obese Chinese children

Previous studies demonstrated a role of variations in sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) in obesity and blood lipids. But the associations between SCAP polymorphisms and blood pressure (BP) are not clear. This study aimed to investigate the relations...

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Bibliographic Details
Published in:PloS one 2017-05, Vol.12 (5), p.e0177973-e0177973
Main Authors: Yang, Yi-De, Song, Jie-Yun, Wang, Shuo, Liu, Fang-Hong, Zhang, Yi-Ning, Shang, Xiao-Rui, Wang, Hai-Jun, Ma, Jun
Format: Article
Language:English
Subjects:
Adolescent
Alleles
Analysis
Biology and Life Sciences
Blood
Blood lipids
Blood pressure
Body mass
Body mass index
Body weight
Case-Control Studies
Causes of
Child
Childhood obesity
Children
Cleavage
Female
Gene polymorphism
Genetic diversity
Genetic variation
Humans
Hypertension
Hypertension - genetics
Insulin resistance
Intracellular Signaling Peptides and Proteins - genetics
Lipids
Male
Medicine and Health Sciences
Membrane Proteins - genetics
Obesity
Obesity - genetics
Obesity - pathology
Overweight
Overweight - genetics
Overweight - pathology
People and Places
Polymorphism
Polymorphism, Single Nucleotide - genetics
Population studies
Protein binding
Regression analysis
Regression models
Risk Factors
Single-nucleotide polymorphism
Sterol regulatory element-binding protein
Studies
Teenagers
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Summary:Previous studies demonstrated a role of variations in sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) in obesity and blood lipids. But the associations between SCAP polymorphisms and blood pressure (BP) are not clear. This study aimed to investigate the relationship between genetic variations in SCAP and BP phenotypes in a Chinese pediatric population. A case-control study on 702 high blood pressure (HBP) children and 1319 controls was conducted to explore the correlation between single nucleotide polymorphism markers (rs12487736 and rs12490383) of SCAP and BP phenotypes. The associations with continuous and categorical variables were examined by linear regression and logistic regression models under a dominant genetic model for the minor rs12487736 A allele and rs12490383 T allele. The rs12487736 polymorphism was significantly associated with systolic BP (SBP) (β = 1.66, P = 0.003) and diastolic BP (DBP) (β = 1.35, P = 0.024) with age, age-squared, sex, study population and body mass index (BMI) adjusted under the dominant genetic model. The rs12490383 polymorphism was significantly associated with SBP (β = 1.71, P = 0.004) and SHBP (OR = 1.39, 95%CI: 1.04-1.86, P = 0.027). When analyzed by BMI categories, in the normal-weight children, no significant association between the SCAP polymorphisms and BP phenotypes was observed (all P > 0.05). However, in the overweight/obese children, rs12487736 was significantly associated with SBP (β = 1.6, P = 0.019) and SHBP (OR = 1.36, 95%CI: 1.02-1.82; P = 0.037), rs12490383 was associated with SBP (β = 2.04, P = 0.004) and SHBP (OR = 1.50, 95%CI: 1.10-2.05; P = 0.01). This study demonstrated that SCAP rs12487736 and rs12490383 were significantly associated with SBP and SHBP in overweight/obese Chinese children. It provided the evidence for association of SCAP with SBP.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0177973