Plasma 1-deoxysphingolipids are early predictors of incident type 2 diabetes mellitus

1-Deoxysphingolipids (1-deoxySLs) are atypical sphingolipids, which are formed in a side reaction during sphingolipid de-novo synthesis. Recently, we demonstrated that 1-deoxySLs are biomarkers for the prediction of T2DM in obese, non-diabetic patients. Here we investigated the relevance of 1-deoxyS...

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Bibliographic Details
Published in:PloS one 2017-05, Vol.12 (5), p.e0175776-e0175776
Main Authors: Mwinyi, J, Boström, A, Fehrer, I, Othman, A, Waeber, G, Marti-Soler, H, Vollenweider, P, Marques-Vidal, P, Schiöth, H B, von Eckardstein, A, Hornemann, T
Format: Article
Language:English
Subjects:
Adiponectin
Aged
Amino acids
Biology
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Blood Glucose - metabolism
Body mass
Chemical synthesis
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetic neuropathy
Fasting
Female
Glucose
Hip
Hospitals
Humans
Incidence
Insulin resistance
Laboratory testing
Lipids
Male
Medicine
Medicine and Health Sciences
Metabolic syndrome
Middle Aged
Neurosciences
Obesity
Pharmacology
Physical Sciences
Plasmas (physics)
Population studies
Predictions
Regression analysis
Sphinganine
Sphingolipids
Sphingolipids - blood
Triglycerides
Type 2 diabetes
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Summary:1-Deoxysphingolipids (1-deoxySLs) are atypical sphingolipids, which are formed in a side reaction during sphingolipid de-novo synthesis. Recently, we demonstrated that 1-deoxySLs are biomarkers for the prediction of T2DM in obese, non-diabetic patients. Here we investigated the relevance of 1-deoxySLs as long-term predictive biomarkers for the incidence of T2DM in an asymptomatic population. Here, we analyzed the plasma sphingoid base profile in a nested group of non-diabetic individuals (N = 605) selected from a population-based study including 5 year follow-up data (CoLaus study). 1-DeoxySLs at baseline were significantly elevated in individuals who developed T2DM during the follow-up (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0175776