Effect of a probiotic beverage consumption (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) in rats with chemically induced colitis

Some probiotic strains have the potential to assist in relieving the symptoms of inflammatory bowel disease. The impact of daily ingestion of a soy-based product fermented by Enterococcus faecium CRL 183 and Lactobacillus helveticus 416 with the addition of Bifidobacterium longum ATCC 15707 on chemi...

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Bibliographic Details
Published in:PloS one 2017-04, Vol.12 (4), p.e0175935-e0175935
Main Authors: Celiberto, Larissa Sbaglia, Bedani, Raquel, Dejani, Naiara Naiana, Ivo de Medeiros, Alexandra, Sampaio Zuanon, José Antonio, Spolidorio, Luis Carlos, Tallarico Adorno, Maria Angela, Amâncio Varesche, Maria Bernadete, Carrilho Galvão, Fábio, Valentini, Sandro Roberto, Font de Valdez, Graciela, Rossi, Elizeu Antonio, Cavallini, Daniela Cardoso Umbelino
Format: Article
Language:English
Subjects:
Acetic acid
Animal models
Animals
Bacteria
Beverages
Bifidobacterium longum
Biology and Life Sciences
Cell growth
Colitis
Colitis - chemically induced
Colitis - drug therapy
Colitis - microbiology
Colon
Cytokines
Dextran
Dextran Sulfate
Disease Models, Animal
Enterococcus faecium
Fatty acids
Fatty Acids, Volatile - analysis
Fecal microflora
Feces - chemistry
Feces - microbiology
Fermented food
Gene expression
Immune system
Inflammatory bowel disease
Inflammatory bowel diseases
Ingestion
Internet
Intestine
Intestines - microbiology
Lactobacillus helveticus
Medicine and Health Sciences
Microorganisms
Organic chemistry
Pathogenesis
Probiotics
Probiotics - therapeutic use
Propionic acid
Rats
Rodents
Signs and symptoms
Studies
Sulfasalazine
Survival
Treatment Outcome
Tumor necrosis factor-TNF
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Summary:Some probiotic strains have the potential to assist in relieving the symptoms of inflammatory bowel disease. The impact of daily ingestion of a soy-based product fermented by Enterococcus faecium CRL 183 and Lactobacillus helveticus 416 with the addition of Bifidobacterium longum ATCC 15707 on chemically induced colitis has been investigated thereof within a period of 30 days. Colitis was induced by dextran sulfate sodium. The animals were randomly assigned into five groups: Group C: negative control; Group CL: positive control; Group CLF: DSS with the fermented product; Group CLP: DSS with the non-fermented product (placebo); Group CLS: DSS with sulfasalazine. The following parameters were monitored: disease activity index, fecal microbial analyses, gastrointestinal survival of probiotic microorganisms and short-chain fatty acids concentration in the feces. At the end of the protocol the animals' colons were removed so as to conduct a macroscopical and histopathological analysis, cytokines and nitrite quantification. Animals belonging to the CLF group showed fewer symptoms of colitis during the induction period and a lower degree of inflammation and ulceration in their colon compared to the CL, CLS and CLP groups (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0175935