The association between frequent alcohol drinking and opioid consumption after abdominal surgery: A retrospective analysis

It is perceived that patients with a history of frequent alcohol consumption require more opioids for postoperative pain control and experience less postoperative nausea and vomiting than patients without such a history. However, there is scarce evidence supporting this notion. The aim of this study...

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Bibliographic Details
Published in:PloS one 2017-03, Vol.12 (3), p.e0171275-e0171275
Main Authors: Kao, Sheng-Chin, Tsai, Hsin-I, Cheng, Chih-Wen, Lin, Ta-Wei, Chen, Chien-Chuan, Lin, Chia-Shiang
Format: Article
Language:English
Subjects:
Abdomen - surgery
Abdominal surgery
Adult
Aged
Aged, 80 and over
Alcohol Drinking
Alcohol use
Alcohols
Analgesia
Analgesia, Patient-Controlled
Analgesics, Opioid - administration & dosage
Analysis
Biology and Life Sciences
Body weight
Consumption
Demographic variables
Demographics
Dosage and administration
Drinking
Drinking (Alcoholic beverages)
Drinking behavior
Female
Health aspects
Humans
Intravenous administration
Kinases
Male
Medical records
Medicine and Health Sciences
Middle Aged
Morphine
Multiple regression analysis
Narcotics
Nausea
Opioids
Pain
Pain management
Pain perception
Pain, Postoperative - drug therapy
Patient satisfaction
Patients
Postoperative Nausea and Vomiting - etiology
Regression analysis
Retrospective Studies
Rodents
Surgery
Vomiting
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Summary:It is perceived that patients with a history of frequent alcohol consumption require more opioids for postoperative pain control and experience less postoperative nausea and vomiting than patients without such a history. However, there is scarce evidence supporting this notion. The aim of this study was to assess association between frequent alcohol consumption and opioid requirement for postoperative pain control and occurrence of postoperative nausea and vomiting. The medical records for 4143 patients using intravenous patient-control analgesia with opioids after abdominal surgery between January 2010 and September 2013 were obtained, and associations were sought between the cumulative opioid consumption (in intravenous morphine equivalence) per body weight (mg/kg) in the first 2 days after abdominal operation and several demographic and clinical variables by multiple regression analysis. The association between the occurrence of postoperative nausea and vomiting and several demographic and clinical variables was also sought by multiple logistic regression analysis. Frequent alcohol drinking, among other previously reported factors, was associated with increased opioid consumption for postoperative pain control (p < 0.001). The estimate effect of frequent alcohol drinking was 0.117 mg/kg. Frequent alcohol drinking was also associated with decreased risks of postoperative nausea (odds ratio = 0.59, p = 0.003) and vomiting (odds ratio = 0.49, p = 0.026). Frequent alcohol drinking was associated with increased opioid consumption for postoperative pain control and decreased risks of postoperative nausea and vomiting after abdominal surgery.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0171275