Leprosy reactions: The predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)

Leprosy reactions, reversal reactions/RR and erythema nodosum leprosum/ENL, can cause irreversible nerve damage, handicaps and deformities. The study of Mycobacterium leprae-specific serologic responses at diagnosis in the cohort of patients enrolled at the Clinical Trial for Uniform Multidrug Thera...

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Published in:PLoS neglected tropical diseases 2017-02, Vol.11 (2), p.e0005396-e0005396
Main Authors: Hungria, Emerith Mayra, Bührer-Sékula, Samira, de Oliveira, Regiane Morillas, Aderaldo, Lúcio Cartaxo, Pontes, Araci de Andrade, Cruz, Rossilene, Gonçalves, Heitor de Sá, Penna, Maria Lúcia Fernandes, Penna, Gerson Oliveira, Stefani, Mariane Martins de Araújo
Format: Article
Language:English
Subjects:
Adult
Analysis
Antibodies, Bacterial - blood
Antigen-antibody reactions
Antigens
Biology and Life Sciences
Brazil
Care and treatment
Clinical trials
Diagnosis
Enzyme-Linked Immunosorbent Assay
Female
Funding
Health aspects
Humans
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin M - blood
Immunoglobulins
Laboratories
Leprosy
Leprosy - diagnosis
Male
Medicine and Health Sciences
Mycobacterium leprae - immunology
Predictive Value of Tests
Prognosis
Research and Analysis Methods
Sensitivity and Specificity
Serologic Tests - methods
Tropical diseases
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Summary:Leprosy reactions, reversal reactions/RR and erythema nodosum leprosum/ENL, can cause irreversible nerve damage, handicaps and deformities. The study of Mycobacterium leprae-specific serologic responses at diagnosis in the cohort of patients enrolled at the Clinical Trial for Uniform Multidrug Therapy Regimen for Leprosy Patients in Brazil/U-MDT/CT-BR is suitable to evaluate its prognostic value for the development of reactions. IgM and IgG antibody responses to PGL-I, LID-1, ND-O-LID were evaluated by ELISA in 452 reaction-free leprosy patients at diagnosis, enrolled and monitored for the development of leprosy reactions during a total person-time of 780,930 person-days, i.e. 2139.5 person-years, with a maximum of 6.66 years follow-up time. Among these patients, 36% (160/452) developed reactions during follow-up: 26% (119/452) RR and 10% (41/452) had ENL. At baseline higher anti-PGL-I, anti-LID-1 and anti-ND-O-LID seropositivity rates were seen in patients who developed ENL and RR compared to reaction-free patients (p
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0005396