Low cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy

Perinatal vitamin D deficiency is associated with a higher risk of wheezing in childhood. However, the relationship between vitamin D levels and lung function in infancy has not been investigated. The aim of this study was to investigate the impact of perinatal vitamin D levels on respiratory functi...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2017-03, Vol.12 (3), p.e0173268-e0173268
Main Authors: Lai, Shen-Hao, Liao, Sui-Ling, Tsai, Ming-Han, Hua, Man-Chin, Chiu, Chih-Yung, Yeh, Kuo-Wei, Yao, Tsung-Chieh, Huang, Jing-Long
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Age
Allergies
Analysis
Asthma
Babies
Biology and Life Sciences
Biomarkers
Breathing
Childhood
Children
Cohort analysis
Cord blood
Data collection
Expiration
Female
Fetal Blood
Gene expression
Guardians
Health risk assessment
Health risks
Humans
Infant
Infants
Infections
Lung - physiopathology
Lung diseases
Lungs
Male
Medicine and Health Sciences
Pediatrics
People and Places
Physical sciences
Pulmonary function tests
Research and Analysis Methods
Respiratory function
Respiratory Function Tests
Respiratory system
Respiratory tract
Respiratory tract diseases
Respiratory tract infection
Respiratory Tract Infections - blood
Respiratory Tract Infections - etiology
Respiratory Tract Infections - physiopathology
Risk Factors
Streptococcus infections
Studies
Suicides & suicide attempts
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D deficiency
Vitamin deficiency
Wheezing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Perinatal vitamin D deficiency is associated with a higher risk of wheezing in childhood. However, the relationship between vitamin D levels and lung function in infancy has not been investigated. The aim of this study was to investigate the impact of perinatal vitamin D levels on respiratory function and disease outcome in infancy. Full-term infants without any chronic diseases or major anomalies were enrolled in the Prediction of Allergies in Taiwanese Children cohort study. Maternal and cord blood were collected for determining the 25(OH)D level. Questionnaires were recorded at birth and 6 months of age. Infant lung function, including tidal breathing analysis, respiratory mechanics, and forced tidal expiration, was tested at 6 months of age. A total of 122 mother-infant pairs were enrolled in this study, and 71 infants underwent lung function testing at 6 months of age. 25(OH)D levels in maternal and cord serum were highly correlated (r2 = 0.457, p < 0.0001). Infants with lower cord serum 25(OH)D levels (< 13.7 ng/ml) had higher resistance of respiratory system (p < 0.01) and a higher risk of a respiratory tract infection before the age of 6 months (p < 0.01). Although a high correlation was found between maternal and cord vitamin D levels, the effect on respiratory outcome was different. Our study is the first to show that low cord 25(OH)D levels significantly relationship with poorer lung function performance and higher likelihood of a respiratory tract infection before 6 months of age.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0173268