Prevalence of and Associated Risk Factors for High Risk Human Papillomavirus among Sexually Active Women, Swaziland

High risk human papillomavirus (hr-HPV) infection and the dual burden of HIV remains a huge challenge in some low-income countries (LICs) such as Swaziland with limited or no data. We estimated the prevalence and investigated determinants of hr-HPV, including HIV infection among sexually active wome...

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Bibliographic Details
Published in:PloS one 2017, Vol.12 (1), p.e0170189-e0170189
Main Authors: Ginindza, Themba G, Dlamini, Xolisile, Almonte, Maribel, Herrero, Rolando, Jolly, Pauline E, Tsoka-Gwegweni, Joyce M, Weiderpass, Elisabete, Broutet, Nathalie, Sartorius, Benn
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adolescent
Adult
AIDS
AIDS Serodiagnosis
Biology and Life Sciences
Community medicine, Social medicine: 801
Cross-Sectional Studies
Demographic aspects
Epidemiology
Eswatini - epidemiology
Female
Health aspects
Health care facilities
Health risk assessment
Health risks
Health sciences: 800
Helsefag: 800
HIV
HIV infections
HIV Infections - complications
HIV Infections - diagnosis
Human immunodeficiency virus
Human papillomavirus
Humans
Infections
Lentivirus
Medical disciplines: 700
Medicin och hälsovetenskap
Medicine and Health Sciences
Medisinske Fag: 700
Middle Aged
Papillomaviridae
Papillomavirus infections
Papillomavirus Infections - complications
Papillomavirus Infections - epidemiology
People and Places
Prevalence
Prevention
Retroviridae
Risk analysis
Risk Factors
Samfunnsmedisin, sosialmedisin: 801
Sexual behavior
Sexually transmitted diseases
STD
VDP
Women
Womens health
Young Adult
Youth
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Summary:High risk human papillomavirus (hr-HPV) infection and the dual burden of HIV remains a huge challenge in some low-income countries (LICs) such as Swaziland with limited or no data. We estimated the prevalence and investigated determinants of hr-HPV, including HIV infection among sexually active women in Swaziland. A total of 655 women aged between 15 and 49 years from five health facilities were randomly enrolled using a cross-sectional study design. Cervical cells were tested for hr-HPV types using GeneXpert HPV Assays. The overall weighted hr-HPV prevalence was 46.2% (95%CI: 42.8-49.5). Of hr-HPV infected women, 12.4% (95%CI: 8.6-17.5) were HPV16-positive, 13.8% (95%CI:12.0-15.8) were positive for HPV18/45, 26.7% (95%CI: 24.2-29.3) for HPV31/33/35/52/58, 7.6% (95%CI: 7.6-11.9) for HPV51/59 and 11.0%, (95%CI: 7.9-15.3) for HPV39/56/66/68. Prevalence of hr-HPV decreased with increasing age. Overall HIV prevalence remained high (42.7%; 95%CI: 35.7-46.2). HIV infection was associated with hr-HPV infection (Adjusted OR = 4.9, 95%CI: 3.043-7.8, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0170189