Intensive versus Guideline Blood Pressure and Lipid Lowering in Patients with Previous Stroke: Main Results from the Pilot 'Prevention of Decline in Cognition after Stroke Trial' (PODCAST) Randomised Controlled Trial

Stroke is associated with the development of cognitive impairment and dementia. We assessed the effect of intensive blood pressure (BP) and/or lipid lowering on cognitive outcomes in patients with recent stroke in a pilot trial. In a multicentre, partial-factorial trial, patients with recent stroke,...

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Bibliographic Details
Published in:PloS one 2017-01, Vol.12 (1), p.e0164608
Main Authors: Bath, Philip M, Scutt, Polly, Blackburn, Daniel J, Ankolekar, Sandeep, Krishnan, Kailash, Ballard, Clive, Burns, Alistair, Mant, Jonathan, Passmore, Peter, Pocock, Stuart, Reckless, John, Sprigg, Nikola, Stewart, Rob, Wardlaw, Joanna M, Ford, Gary A
Format: Article
Language:English
Subjects:
Aged
Analysis
Biology and Life Sciences
Blood
Blood pressure
Blood Pressure - drug effects
Cholesterol
Clinical trials
Cognition
Cognition & reasoning
Cognition Disorders - etiology
Cognition Disorders - prevention & control
Cognitive ability
Cognitive disorders
Complications and side effects
Dementia
Dementia disorders
Female
Geriatrics
Hospitals
Humans
Hypertension
Hypolipidemic Agents - therapeutic use
Lipids
Lipids - blood
Lipoproteins (low density)
Low density lipoprotein
Male
Medicine and Health Sciences
Neurosciences
Nitric oxide
Patients
Podcasts
Practice Guidelines as Topic
Pressure effects
Prevention
Prospective Studies
Psychiatry
Risk factors
Stroke
Stroke - complications
Stroke Rehabilitation
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Summary:Stroke is associated with the development of cognitive impairment and dementia. We assessed the effect of intensive blood pressure (BP) and/or lipid lowering on cognitive outcomes in patients with recent stroke in a pilot trial. In a multicentre, partial-factorial trial, patients with recent stroke, absence of dementia, and systolic BP (SBP) 125-170 mmHg were assigned randomly to at least 6 months of intensive (target SBP
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0164608