In Vivo, Non-Invasive Characterization of Human Bone by Hybrid Broadband (600-1200 nm) Diffuse Optical and Correlation Spectroscopies

Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal,...

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Bibliographic Details
Published in:	PloS one 2016-12, Vol.11 (12), p.e0168426-e0168426
Main Authors:	Konugolu Venkata Sekar, Sanathana, Pagliazzi, Marco, Negredo, Eugènia, Martelli, Fabrizio, Farina, Andrea, Dalla Mora, Alberto, Lindner, Claus, Farzam, Parisa, Pérez-Álvarez, Núria, Puig, Jordi, Taroni, Paola, Pifferi, Antonio, Durduran, Turgut
Format:	Article
Language:	eng
Subjects:	90 Operations research, mathematical programming Adult Biology and Life Sciences Blood Blood flow Bone blood flow Bone density Bones Broadband Calcaneus Care and treatment Classificació AMS Collagen Contrast agents Correlation Diagnostic imaging Female Humans Innovations Investigació operativa Lipids Male Matemàtiques i estadística Medical imaging Medicine and Health Sciences Metabolism Microvasculature Middle Aged NMR Nuclear magnetic resonance Observations Optical properties Osteoporosis Oxygen Oxygen Consumption Oxygen consumption (Metabolism) Oxygen metabolism Patient care Patients Penetration depth Perfusion Physical Sciences Physiology Point-of-Care Systems Radius Radius - diagnostic imaging Radius - metabolism Research and Analysis Methods Spectrophotometry - instrumentation Spectrophotometry - methods Spectroscopy Spectrum analysis Technology application Tissues Tomography, Optical Coherence - instrumentation Tomography, Optical Coherence - methods Trochanter Ulna Ulna - diagnostic imaging Ulna - metabolism Àrees temàtiques de la UPC
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Summary:	Non-invasive in vivo diffuse optical characterization of human bone opens a new possibility of diagnosing bone related pathologies. We present an in vivo characterization performed on seventeen healthy subjects at six different superficial bone locations: radius distal, radius proximal, ulna distal, ulna proximal, trochanter and calcaneus. A tailored diffuse optical protocol for high penetration depth combined with the rather superficial nature of considered tissues ensured the effective probing of the bone tissue. Measurements were performed using a broadband system for Time-Resolved Diffuse Optical Spectroscopy (TRS) to assess mean absorption and reduced scattering spectra in the 600-1200 nm range and Diffuse Correlation Spectroscopy (DCS) to monitor microvascular blood flow. Significant variations among tissue constituents were found between different locations; with radius distal rich of collagen, suggesting it as a prominent location for bone related measurements, and calcaneus bone having highest blood flow among the body locations being considered. By using TRS and DCS together, we are able to probe the perfusion and oxygen consumption of the tissue without any contrast agents. Therefore, we predict that these methods will be able to evaluate the impairment of the oxygen metabolism of the bone at the point-of-care.
ISSN:	1932-6203 1932-6203