Faecal Carriage of Gram-Negative Multidrug-Resistant Bacteria among Patients Hospitalized in Two Centres in Ulaanbaatar, Mongolia

Gram-negative multidrug-resistant organisms (GN-MDRO) producing β-lactamases (ESBL, plasmid-mediated AmpC β-lactamases and carbapenemases) are increasingly reported throughout Asia. The aim of this surveillance study was to determine the rate of bacterial colonization in patients from two hospitals...

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Bibliographic Details
Published in:PloS one 2016-12, Vol.11 (12), p.e0168146-e0168146
Main Authors: Baljin, Bayaraa, Baldan, Ganbaatar, Chimeddorj, Battogtokh, Tulgaa, Khosbayar, Gunchin, Batbaatar, Sandag, Tsogtsaikhan, Pfeffer, Klaus, MacKenzie, Colin R, Wendel, Andreas F
Format: Article
Language:English
Subjects:
Acinetobacter
Acinetobacter baumannii
Adolescent
Adult
Aged
Aged, 80 and over
Analysis
Antibiotics
Antimicrobial agents
Bacteria
Bacterial Proteins - biosynthesis
beta-Lactamases - biosynthesis
beta-Lactamases - genetics
Biology and Life Sciences
Burn treatment
Carbapenemase
Carrier State - epidemiology
Chemotherapy
Child
Child, Preschool
Childrens health
Colonization
Cross Infection - epidemiology
Cross Infection - microbiology
Drug resistance
Drug Resistance, Multiple
E coli
Enterobacteriaceae
Enzymes
Epidemiology
Escherichia coli
Feces - microbiology
Female
Genes
Genotype
Gram-negative bacteria
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - genetics
Gram-Negative Bacteria - isolation & purification
Gram-Negative Bacterial Infections - epidemiology
Gram-Negative Bacterial Infections - microbiology
Hospitalization
Hospitals
Humans
Hygiene
Immunology
Infant
Infections
Infectious diseases
Intensive care
Klebsiella pneumoniae
Male
Maternal & child health
Medicine and Health Sciences
Microbial colonies
Microbial drug resistance
Microbial Sensitivity Tests
Middle Aged
Mongolia - epidemiology
Multidrug resistance
Multidrug resistant organisms
Patients
People and Places
Plasmids
Population studies
Prevalence
Pseudomonas aeruginosa
Rectum
Reorganization and restructuring
Selective media
Sentinel surveillance
Surgery
Surveillance
Trauma
Young Adult
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Summary:Gram-negative multidrug-resistant organisms (GN-MDRO) producing β-lactamases (ESBL, plasmid-mediated AmpC β-lactamases and carbapenemases) are increasingly reported throughout Asia. The aim of this surveillance study was to determine the rate of bacterial colonization in patients from two hospitals in the Mongolian capital Ulaanbaatar. Rectal swabs were obtained from patients referred to the National Traumatology and Orthopaedics Research Centre (NTORC) or the Burn Treatment Centre (BTC) between July and September 2014, on admission and again after 14 days. Bacteria growing on selective chromogenic media (CHROMagar ESBL/KPC) were identified by MALDI-ToF MS. We performed susceptibility testing by disk diffusion and PCR (blaIMP-1, blaVIM, blaGES, blaNDM, blaKPC, blaOXA-48, blaGIM-1, blaOXA-23, blaOXA-24/40, blaOXA-51, blaOXA-58, blaOXA-143, blaOXA-235, blaCTX-M, blaSHV blaTEM and plasmid-mediated blaAmpC). Carbapenemase-producing isolates were additionally genotyped by PFGE and MLST. During the study period 985 patients in the NTORC and 65 patients in the BTC were screened on admission. The prevalence of GN-MDRO-carriage was 42.4% and 69.2% respectively (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0168146