Compromised Defenses: Exploitation of Epithelial Responses During Viral-Bacterial Co-Infection of the Respiratory Tract

First and foremost, the epithelium is a physical barrier to pathogen invasion, forming cell-cell junctions to exclude pathogens from the underlying tissues and actively restrict nutrient availability. Viral Infection Increases Bacterial Adherence to the Respiratory Epithelium Viral infection of resp...

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Bibliographic Details
Published in:PLoS pathogens 2016-09, Vol.12 (9), p.e1005797-e1005797
Main Authors: Melvin, Jeffrey A, Bomberger, Jennifer M
Format: Article
Language:English
Subjects:
Analysis
Animals
Antimicrobial agents
Bacterial infections
Bacterial Infections - immunology
Bacterial Infections - microbiology
Biofilms
Biology and Life Sciences
Biosynthesis
Chemokines
Coinfection - immunology
Coinfection - microbiology
Cystic fibrosis
Cytokines
Ear diseases
Epithelium
Funding
Humans
Immune response
Influenza
Medicine and Health Sciences
Neutrophils
Pathogens
Pearls
Proteins
Respiratory Mucosa - immunology
Respiratory Mucosa - microbiology
Respiratory tract infections
Respiratory Tract Infections - immunology
Respiratory Tract Infections - microbiology
Streptococcus infections
Studies
Viral infections
Virus Diseases - immunology
Virus Diseases - microbiology
Viruses
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Summary:First and foremost, the epithelium is a physical barrier to pathogen invasion, forming cell-cell junctions to exclude pathogens from the underlying tissues and actively restrict nutrient availability. Viral Infection Increases Bacterial Adherence to the Respiratory Epithelium Viral infection of respiratory epithelium can increase bacterial adherence and colonization (as well as viral adherence) through multiple distinct mechanisms (Fig 1A).\n We have recently demonstrated that iron levels are increased in the airway surface liquid during respiratory syncytial virus infection, in the form of transferrin-bound iron [28]. [...]this increase in iron availability is required for virus-induced bacterial biofilm growth by P. aeruginosa (Fig 1C).
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1005797