Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison

Real-time shear wave elastography (2D-SWE) is a two-dimensional transient elastography and a competitor as a biomarker of liver fibrosis in comparison with the standard reference transient elastography by M probe (TE-M). The aims were to compare several criteria of applicability, and to assess infla...

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Bibliographic Details
Published in:PloS one 2016-10, Vol.11 (10), p.e0163276-e0163276
Main Authors: Poynard, Thierry, Pham, Tam, Perazzo, Hugo, Munteanu, Mona, Luckina, Elena, Elaribi, Djamel, Ngo, Yen, Bonyhay, Luminita, Seurat, Noemie, Legroux, Muriel, Ngo, An, Deckmyn, Olivier, Thabut, Dominique, Ratziu, Vlad, Lucidarme, Olivier
Format: Article
Language:English
Subjects:
Analysis
Area Under Curve
Bioengineering
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Biopsy
Blood tests
Body mass
Body mass index
Body size
Criteria
Curve fitting
Elasticity
Elasticity Imaging Techniques - methods
Fatty Liver - diagnostic imaging
Fatty Liver - epidemiology
Fatty Liver - pathology
Female
Fibrosis
Gastroenterology
Hepatitis
Hepatology
Human health and pathology
Humans
Hépatology and Gastroenterology
Imaging
Impact prediction
Inflammation
Inflammation - diagnostic imaging
Inflammation - pathology
Interferon
Life Sciences
Liver
Liver Cirrhosis - diagnosis
Liver Cirrhosis - diagnostic imaging
Liver diseases
Male
Medicine and Health Sciences
Middle Aged
Multivariate Analysis
Patients
Population
Real time
Regression analysis
Research and Analysis Methods
ROC Curve
Severity of Illness Index
Standardization
Steatosis
Systematic review
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Summary:Real-time shear wave elastography (2D-SWE) is a two-dimensional transient elastography and a competitor as a biomarker of liver fibrosis in comparison with the standard reference transient elastography by M probe (TE-M). The aims were to compare several criteria of applicability, and to assess inflammation and steatosis impact on elasticity values, two unmet needs. We took FibroTest as the fibrosis reference and ActiTest and SteatoTest as quantitative estimates of inflammation and steatosis. After standardization of estimates, analyses used curve fitting, quantitative Lin concordance coefficient [LCC], and multivariate logistic regression. A total of 2,251 consecutive patients were included. We validated the predetermined 0.2 kPa cut-off as a too low minimal elasticity value identifying not-reliable 2D-SWE results (LCC with FibroTest = 0.0281[-0.119;0.175]. Other criteria, elasticity CV, body mass index and depth of measures were not sufficiently discriminant. The applicability of 2D-SWE (95%CI) 89.6%(88.2-90.8), was significantly higher than that of TE, 85.6%(84.0-87.0; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0163276