Association between the HFE C282Y, H63D Polymorphisms and the Risks of Non-Alcoholic Fatty Liver Disease, Liver Cirrhosis and Hepatocellular Carcinoma: An Updated Systematic Review and Meta-Analysis of 5,758 Cases and 14,741 Controls

Conflicting results have been obtained for the association between two common polymorphisms (C282Y, H63D) of human HFE (hereditary hemochromatosis) gene and the risks of the liver diseases, including non-alcoholic fatty liver disease (NAFLD), liver cirrhosis and hepatocellular carcinoma (HCC). An up...

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Bibliographic Details
Published in:PloS one 2016-09, Vol.11 (9), p.e0163423-e0163423
Main Authors: Ye, Qing, Qian, Bao-Xin, Yin, Wei-Li, Wang, Feng-Mei, Han, Tao
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Cardiovascular disease
Cirrhosis
Disease susceptibility
Fatty liver
Gastroenterology
Gene polymorphism
Genes
Genetic aspects
Genetic polymorphisms
Health risks
Hemochromatosis
Hepatitis
Hepatocellular carcinoma
Hepatology
Heterozygosity
Heterozygotes
Hospitals
Laboratories
Liver
Liver cancer
Liver cirrhosis
Liver diseases
Medicine and Health Sciences
Meta-analysis
Mutation
Online databases
Physical Sciences
Polymorphism
Population (statistical)
Population genetics
Proteins
Research and Analysis Methods
Statistical analysis
Systematic review
Upgrading
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Summary:Conflicting results have been obtained for the association between two common polymorphisms (C282Y, H63D) of human HFE (hereditary hemochromatosis) gene and the risks of the liver diseases, including non-alcoholic fatty liver disease (NAFLD), liver cirrhosis and hepatocellular carcinoma (HCC). An updated systematic review and meta-analysis was conducted to evaluate the potential role of HFE polymorphisms in the susceptibility to NAFLD, liver cirrhosis and HCC. After retrieving articles from online databases, eligible studies were enrolled according to the selection criteria. Stata/SE 12.0 software was utilized to perform the statistical analysis. In total, 43 articles with 5,758 cases and 14,741 controls were selected. Compared with the control group, a significantly increased risk of NAFLD was observed for the C282Y polymorphism in the Caucasian population under all genetic models and for the H63D polymorphism under the allele, heterozygote and dominant models (all OR>1, Passociation0.05). In addition, we found that HFE C282Y was statistically associated with increased HCC susceptibility in the overall population, while H63D increased the odds of developing non-cirrhotic HCC in the African population (all OR>1, Passociation
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0163423