Expanding Host Range and Cross-Species Infection of Hepatitis E Virus

According to the World Health Organization, each year an estimated 20 million infections occur worldwide resulting in >3 million symptomatic cases and 56,600 hepatitis E-related deaths (http://www.who.int/mediacentre/factsheets/fs280/en/). Hel, helicase; HVR, hypervariable region; MT, methytransf...

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Bibliographic Details
Published in:PLoS pathogens 2016-08, Vol.12 (8), p.e1005695-e1005695
Main Author: Meng, Xiang-Jin
Format: Article
Language:English
Subjects:
Animals
Biology and life sciences
Food
Genomes
Genotype & phenotype
Genotypes
Health aspects
Heparan sulfate
Hepatitis
Hepatitis E
Hepatitis E - transmission
Hepatitis E - virology
Hepatitis E virus
Hogs
Host Specificity
Humans
Identification
Infections
Meat
Medicine and health sciences
Moose
Mortality
Pearls
Pregnant women
Proteins
Research and Analysis Methods
Risk factors
RNA polymerase
Transplants & implants
Viruses
Zoonoses
Zoonoses - transmission
Zoonoses - virology
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Summary:According to the World Health Organization, each year an estimated 20 million infections occur worldwide resulting in >3 million symptomatic cases and 56,600 hepatitis E-related deaths (http://www.who.int/mediacentre/factsheets/fs280/en/). Hel, helicase; HVR, hypervariable region; MT, methytransferase; NCR, noncoding region; P, a papain-like cysteine protease; RdRp, RNA-dependent RNA polymerase; X, macro domain. http://dx.doi.org/10.1371/journal.ppat.1005695.g001 Identification of genetically distinct strains of HEV from a number of animal species led to the recent division of the family Hepeviridae into two genera by the International Committee on Taxonomy of Viruses (ICTV): genus Orthohepevirus (all mammalian and avian HEV isolates) and genus Piscihepevirus (cutthroat trout virus) [5]. Chronic hepatitis E associated with genotype 3 or 4 HEV infections has recently become an important clinical problem in organ transplant recipients and other immunocompromised individuals, thus prompting a need for developing effective anti-HEV drugs and vaccines.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1005695