Effect of Strength Training on Oxidative Stress and the Correlation of the Same with Forearm Vasodilatation and Blood Pressure of Hypertensive Elderly Women: A Randomized Clinical Trial

The aim of the study was to evaluate the effect of strength training on oxidative stress and the correlation of the same with forearm vasodilatation and mean blood pressure of hypertensive elderly women, at rest (basal) and during a static handgrip exercise. Insufficiently active hypertensive elderl...

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Published in:	PloS one 2016-08, Vol.11 (8), p.e0161178-e0161178
Main Authors:	Dantas, Filipe Fernandes Oliveira, Brasileiro-Santos, Maria do Socorro, Batista, Rafael Marinho Falcão, do Nascimento, Leone Severino, Castellano, Lúcio Roberto Cançado, Ritti-Dias, Raphael Mendes, Lima, Kenio Costa, Santos, Amilton da Cruz
Format:	Article
Language:	eng
Subjects:	Aged Aging Antioxidants Biology and Life Sciences Biomarkers - blood Blood Blood diseases Blood flow Blood Pressure Blood vessels Care and treatment Clinical trials Complications and side effects Conductance Correlation Dilatation Exercise Female Fitness training programs Forearm Forearm - blood supply Geriatrics Heart Humans Hypertension Hypertension - blood Hypertension - metabolism Hypertension - physiopathology Hypertension - therapy Laboratories Malondialdehyde Medicine and Health Sciences Musculoskeletal system Nitrogen dioxide Older people Oxidative Stress People and Places Physical education Physical fitness Physiological aspects Physiology Resistance Training Rest - physiology Rodents Sports training Strength Strength training Training Vasodilation Weight training Womens health
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Summary:	The aim of the study was to evaluate the effect of strength training on oxidative stress and the correlation of the same with forearm vasodilatation and mean blood pressure of hypertensive elderly women, at rest (basal) and during a static handgrip exercise. Insufficiently active hypertensive elderly women (N = 25; mean age = 66.1 years) were randomized into a 10 week strength training group (n = 13) or control (n = 12) group. Plasma malondialdehyde (MDA), total antioxidant capacity (TAC), plasma nitrite (NO2-), forearm blood flow (FBF), mean blood pressure (MBP) and vascular conductance ([FBF / MBP] x 100) were evaluated before and after the completion of the interventions. The strength training group increased the TAC (pre: Median = 39.0; Interquartile range = 34.0-41.5% vs post: Median = 44.0; Interquartile range = 38.0-51.5%; p = 0.006) and reduced the MDA (pre: 4.94 ± 1.10 μM vs post: 3.90 ± 1.35 μM; p = 0.025; CI-95%: -1.92 --0.16 μM). The strength training group increased basal vascular conductance (VC) (pre: 3.56 ±0.88 units vs post: 5.21 ±1.28 units; p = 0.001; CI-95%: 0.93-2.38 units) and decreased basal MBP (pre: 93.1 ±6.3 mmHg vs post: 88.9 ±5.4 mmHg; p = 0.035; CI-95%: -8.0 --0.4 mmHg). Such changes were also observed during static handgrip exercise. A moderate correlation was observed between changes in basal VC and MBP with changes in NO2- (ΔVC → r = -0.56, p = 0.047; ΔMBP → r = -0.41, p = 0.168) and MDA (ΔVC → r = 0.64, p = 0.019; ΔMBP → r = 0.31, p = 0.305). The strength training program reduced the oxidative stress of the hypertensive elderly women and this reduction was moderately correlated with their cardiovascular benefits. ensaiosclinicos.gov.br RBR-48c29w.
ISSN:	1932-6203 1932-6203