Efficacy of Soiled Bedding Transfer for Transmission of Mouse and Rat Infections to Sentinels: A Systematic Review

This systematic review was conducted to gain insight into the efficacy of transmission of infectious agents to colony sentinels by soiled bedding transfer based on publications studying this subject in mice and rats. This information is essential to establish recommendations for the design of health...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2016-08, Vol.11 (8), p.e0158410-e0158410
Main Authors: de Bruin, W C C, van de Ven, E M E, Hooijmans, C R
Format: Article
Language:English
Subjects:
Animal experimentation
Animals
Bedding
Biology and Life Sciences
Care and treatment
Clostridium
Colonies
Design
Disease transmission
Disease Transmission, Infectious - veterinary
Dosage
Earth Sciences
Effectiveness
Experiments
Guidelines
Health aspects
Helicobacter
Housing, Animal
Infection
Infection - diagnosis
Infection - transmission
Infection - veterinary
Infections
Infectious diseases
Laboratory animals
Medicine and Health Sciences
Mice
Multipurpose vehicles
Pathogens
Rats
Risk factors
Rodent Diseases - transmission
Rodent Diseases - virology
Sendai virus
Sentinel Surveillance - veterinary
Soil conservation
Studies
Systematic review
Theiler's encephalomyelitis virus
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This systematic review was conducted to gain insight into the efficacy of transmission of infectious agents to colony sentinels by soiled bedding transfer based on publications studying this subject in mice and rats. This information is essential to establish recommendations for the design of health monitoring programs which use sentinels to determine the microbiological status of laboratory animal colonies. Fifteen original articles retrieved from PubMed, Embase, and CAB abstracts met the inclusion criteria. The design of the studies varied substantially per infectious agent with regard to dose of soiled bedding, exposure time, and sentinel strains used. With our conservative criteria for effectiveness, soiled bedding transfer appeared to be effective for MHV, MPV, TMEV, Helicobacter spp., and fur mite infections and ineffective for Sendai virus. For other infectious agents, such as MNV, EDIM, MVM, SDAV, Clostridium piliforme, and pinworms, too few data were available to be able to draw robust conclusions on the efficacy of soiled bedding transfer. The identified evidence only pertains to a portion of the infectious organisms included in the FELASA 2014 guidelines. As many animal facilities design their health monitoring program according to these recommendations, additional studies are warranted to draw comprehensive conclusions on the effective transmission of the infectious agents listed in these guidelines by soiled bedding transfer.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0158410