Dopamine Receptor Gene DRD4 7-Repeat Allele X Maternal Sensitivity Interaction on Child Externalizing Behavior Problems: Independent Replication of Effects at 18 Months

The DRD4 VNTR has been associated with child behavior problems in interaction with maternal insensitivity in European and American cohorts of preschoolers, with the 7-repeat (7R) allele associated with greater problems. We sought to replicate and expand these findings by examining effects on reports...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2016-08, Vol.11 (8), p.e0160473-e0160473
Main Authors: King, Anthony P, Muzik, Maria, Hamilton, Lindsay, Taylor, Alexander B, Rosenblum, Katherine L, Liberzon, Israel
Format: Article
Language:English
Subjects:
African Americans - genetics
Age
Alleles
Attention deficit hyperactivity disorder
Babies
Behavior
Behavior problems
Biology and Life Sciences
Child behavior
Child Behavior Disorders - genetics
Children & youth
Cohort Studies
Depression
Dopamine
Dopamine D4 receptors
Dopamine receptors
European Continental Ancestry Group - genetics
Female
Genetic aspects
Genotypes
Humans
Infant
Infants
Longitudinal Studies
Maternal behavior
Maternal Behavior - psychology
Medical screening
Medicine and Health Sciences
Mental depression
Minisatellite Repeats
Mother-Child Relations
Mothers - psychology
People and Places
Physical Sciences
Preschool children
Psychiatry
Receptors, Dopamine D4 - genetics
Regression analysis
Research and Analysis Methods
Sensitivity
Sensitivity analysis
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c725t-ad0e2ea0b477fe51186c09bf06429bbcf038403288f9963b97d001bad192844d3
cites cdi_FETCH-LOGICAL-c725t-ad0e2ea0b477fe51186c09bf06429bbcf038403288f9963b97d001bad192844d3
container_end_page e0160473
container_issue 8
container_start_page e0160473
container_title PloS one
container_volume 11
creator King, Anthony P
Muzik, Maria
Hamilton, Lindsay
Taylor, Alexander B
Rosenblum, Katherine L
Liberzon, Israel
description The DRD4 VNTR has been associated with child behavior problems in interaction with maternal insensitivity in European and American cohorts of preschoolers, with the 7-repeat (7R) allele associated with greater problems. We sought to replicate and expand these findings by examining effects on reports of child behavior problems at 18 months. A 63 family sample with data for observed maternal sensitivity ratings, DRD4 VNTR genotype, and maternal report of child behavior problems at 18-months was used in this preliminary analysis. Maternal sensitivity was measured at 6-months of age using laboratory observational measures (free-play and a teaching task). Maternal report of toddler behavior was obtained at 18-months via the standard Child Behavior Checklist, and infant genotype on the DRD4 VNTR was obtained using PCR. Infants carrying the DRD4 7R allele showed greater effects of maternal insensitivity than non-carriers for behavioral problems at 18-months. We replicated previous findings of association of infant DRD4 x maternal sensitivity interactions with child Externalizing problems in the European-ancestry sample (N = 42) in a median split of maternal sensitivity (p = .00011, eta2 = .329) and in regression analyses controlling for maternal age, maternal depression, and child gender in European ancestry (B = -3.4, SE 1.33, p = .01) and the total sample (B = -2.2, SE 1.02, p = .02). Exploratory analyses also found evidence of DRD4 x maternal sensitivity interaction with the CBCL ADHD scale. These findings replicate in an independent cohort DRD4 x maternal insensitivity interaction effect on child externalizing behavior problems at 18 months, further supporting the role of the DRD4 genotype in differential sensitivity to parenting.
doi_str_mv 10.1371/journal.pone.0160473
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1812517477</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A460030519</galeid><doaj_id>oai_doaj_org_article_30038642613b4f2ca8d37f01402a6ad9</doaj_id><sourcerecordid>A460030519</sourcerecordid><originalsourceid>FETCH-LOGICAL-c725t-ad0e2ea0b477fe51186c09bf06429bbcf038403288f9963b97d001bad192844d3</originalsourceid><addsrcrecordid>eNqNk9tuEzEQhlcIREvhDRBYQkJwkWCvvScukEpTSqRWRSkg7iyvd5w4ctbL2qlanojHZNKkVYJ6Ue1qD-Nv_vGMZ5LkJaNDxgv2Ye6XfavcsPMtDCnLqSj4o2SfVTwd5Cnlj7e-95JnIcwpzXiZ50-TvbQQlchSup_8HflOLWwLZAIauuh7cgL4N5qMBCkGE-hARXLoHDggv8iZirCKSi6gDTbaSxuvybhFo9LR-pbgfTSzriHHV2vS_rHtlHyGmbq0KP6t97WDRfiIXg2K46ONGLtzVqu1giHHxoCOgWBkVpIz38ZZeJ48McoFeLF5HyQ_vhx_P_o6OD0_GR8dng50kWZxoBoKKShai6IwkDFW5ppWtaG5SKu61obyUlCelqWpqpzXVdFQymrVsCothWj4QfJ6rds5H-SmyEGykqUZK1AVifGaaLyay663C9VfS6-svDH4fipVH612IDnFcBg5Z7wWJtWqbHhhKBM0VblqKtT6tIm2rBfQaCxGr9yO6O5Ka2dy6i-lqIqMVyUKvNsI9P73EkKUCxs0OKda8MubfWcFY5Sxh6CUZzmvOKJv_kPvL8SGmirM1bbG4xb1SlQeihxTpxlbpTi8h8KrgYXV2LzGon3H4f2OAzIRruJULUOQ44vJw9nzn7vs2y12BsphW3m3XHVd2AXFGtS9D6EHc3cejMrV7N1WQ65mT25mD91ebZ_lndPtsPF_CNooMw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1812517477</pqid></control><display><type>article</type><title>Dopamine Receptor Gene DRD4 7-Repeat Allele X Maternal Sensitivity Interaction on Child Externalizing Behavior Problems: Independent Replication of Effects at 18 Months</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database</source><creator>King, Anthony P ; Muzik, Maria ; Hamilton, Lindsay ; Taylor, Alexander B ; Rosenblum, Katherine L ; Liberzon, Israel</creator><contributor>Pawluski, Jodi</contributor><creatorcontrib>King, Anthony P ; Muzik, Maria ; Hamilton, Lindsay ; Taylor, Alexander B ; Rosenblum, Katherine L ; Liberzon, Israel ; Pawluski, Jodi</creatorcontrib><description>The DRD4 VNTR has been associated with child behavior problems in interaction with maternal insensitivity in European and American cohorts of preschoolers, with the 7-repeat (7R) allele associated with greater problems. We sought to replicate and expand these findings by examining effects on reports of child behavior problems at 18 months. A 63 family sample with data for observed maternal sensitivity ratings, DRD4 VNTR genotype, and maternal report of child behavior problems at 18-months was used in this preliminary analysis. Maternal sensitivity was measured at 6-months of age using laboratory observational measures (free-play and a teaching task). Maternal report of toddler behavior was obtained at 18-months via the standard Child Behavior Checklist, and infant genotype on the DRD4 VNTR was obtained using PCR. Infants carrying the DRD4 7R allele showed greater effects of maternal insensitivity than non-carriers for behavioral problems at 18-months. We replicated previous findings of association of infant DRD4 x maternal sensitivity interactions with child Externalizing problems in the European-ancestry sample (N = 42) in a median split of maternal sensitivity (p = .00011, eta2 = .329) and in regression analyses controlling for maternal age, maternal depression, and child gender in European ancestry (B = -3.4, SE 1.33, p = .01) and the total sample (B = -2.2, SE 1.02, p = .02). Exploratory analyses also found evidence of DRD4 x maternal sensitivity interaction with the CBCL ADHD scale. These findings replicate in an independent cohort DRD4 x maternal insensitivity interaction effect on child externalizing behavior problems at 18 months, further supporting the role of the DRD4 genotype in differential sensitivity to parenting.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0160473</identifier><identifier>PMID: 27494520</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>African Americans - genetics ; Age ; Alleles ; Attention deficit hyperactivity disorder ; Babies ; Behavior ; Behavior problems ; Biology and Life Sciences ; Child behavior ; Child Behavior Disorders - genetics ; Children &amp; youth ; Cohort Studies ; Depression ; Dopamine ; Dopamine D4 receptors ; Dopamine receptors ; European Continental Ancestry Group - genetics ; Female ; Genetic aspects ; Genotypes ; Humans ; Infant ; Infants ; Longitudinal Studies ; Maternal behavior ; Maternal Behavior - psychology ; Medical screening ; Medicine and Health Sciences ; Mental depression ; Minisatellite Repeats ; Mother-Child Relations ; Mothers - psychology ; People and Places ; Physical Sciences ; Preschool children ; Psychiatry ; Receptors, Dopamine D4 - genetics ; Regression analysis ; Research and Analysis Methods ; Sensitivity ; Sensitivity analysis ; Studies</subject><ispartof>PloS one, 2016-08, Vol.11 (8), p.e0160473-e0160473</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 King et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 King et al 2016 King et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-ad0e2ea0b477fe51186c09bf06429bbcf038403288f9963b97d001bad192844d3</citedby><cites>FETCH-LOGICAL-c725t-ad0e2ea0b477fe51186c09bf06429bbcf038403288f9963b97d001bad192844d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1812517477/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1812517477?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,730,783,787,888,25767,27938,27939,37026,37027,44604,53806,53808,75462</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27494520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Pawluski, Jodi</contributor><creatorcontrib>King, Anthony P</creatorcontrib><creatorcontrib>Muzik, Maria</creatorcontrib><creatorcontrib>Hamilton, Lindsay</creatorcontrib><creatorcontrib>Taylor, Alexander B</creatorcontrib><creatorcontrib>Rosenblum, Katherine L</creatorcontrib><creatorcontrib>Liberzon, Israel</creatorcontrib><title>Dopamine Receptor Gene DRD4 7-Repeat Allele X Maternal Sensitivity Interaction on Child Externalizing Behavior Problems: Independent Replication of Effects at 18 Months</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The DRD4 VNTR has been associated with child behavior problems in interaction with maternal insensitivity in European and American cohorts of preschoolers, with the 7-repeat (7R) allele associated with greater problems. We sought to replicate and expand these findings by examining effects on reports of child behavior problems at 18 months. A 63 family sample with data for observed maternal sensitivity ratings, DRD4 VNTR genotype, and maternal report of child behavior problems at 18-months was used in this preliminary analysis. Maternal sensitivity was measured at 6-months of age using laboratory observational measures (free-play and a teaching task). Maternal report of toddler behavior was obtained at 18-months via the standard Child Behavior Checklist, and infant genotype on the DRD4 VNTR was obtained using PCR. Infants carrying the DRD4 7R allele showed greater effects of maternal insensitivity than non-carriers for behavioral problems at 18-months. We replicated previous findings of association of infant DRD4 x maternal sensitivity interactions with child Externalizing problems in the European-ancestry sample (N = 42) in a median split of maternal sensitivity (p = .00011, eta2 = .329) and in regression analyses controlling for maternal age, maternal depression, and child gender in European ancestry (B = -3.4, SE 1.33, p = .01) and the total sample (B = -2.2, SE 1.02, p = .02). Exploratory analyses also found evidence of DRD4 x maternal sensitivity interaction with the CBCL ADHD scale. These findings replicate in an independent cohort DRD4 x maternal insensitivity interaction effect on child externalizing behavior problems at 18 months, further supporting the role of the DRD4 genotype in differential sensitivity to parenting.</description><subject>African Americans - genetics</subject><subject>Age</subject><subject>Alleles</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Babies</subject><subject>Behavior</subject><subject>Behavior problems</subject><subject>Biology and Life Sciences</subject><subject>Child behavior</subject><subject>Child Behavior Disorders - genetics</subject><subject>Children &amp; youth</subject><subject>Cohort Studies</subject><subject>Depression</subject><subject>Dopamine</subject><subject>Dopamine D4 receptors</subject><subject>Dopamine receptors</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genotypes</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Longitudinal Studies</subject><subject>Maternal behavior</subject><subject>Maternal Behavior - psychology</subject><subject>Medical screening</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Minisatellite Repeats</subject><subject>Mother-Child Relations</subject><subject>Mothers - psychology</subject><subject>People and Places</subject><subject>Physical Sciences</subject><subject>Preschool children</subject><subject>Psychiatry</subject><subject>Receptors, Dopamine D4 - genetics</subject><subject>Regression analysis</subject><subject>Research and Analysis Methods</subject><subject>Sensitivity</subject><subject>Sensitivity analysis</subject><subject>Studies</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tuEzEQhlcIREvhDRBYQkJwkWCvvScukEpTSqRWRSkg7iyvd5w4ctbL2qlanojHZNKkVYJ6Ue1qD-Nv_vGMZ5LkJaNDxgv2Ye6XfavcsPMtDCnLqSj4o2SfVTwd5Cnlj7e-95JnIcwpzXiZ50-TvbQQlchSup_8HflOLWwLZAIauuh7cgL4N5qMBCkGE-hARXLoHDggv8iZirCKSi6gDTbaSxuvybhFo9LR-pbgfTSzriHHV2vS_rHtlHyGmbq0KP6t97WDRfiIXg2K46ONGLtzVqu1giHHxoCOgWBkVpIz38ZZeJ48McoFeLF5HyQ_vhx_P_o6OD0_GR8dng50kWZxoBoKKShai6IwkDFW5ppWtaG5SKu61obyUlCelqWpqpzXVdFQymrVsCothWj4QfJ6rds5H-SmyEGykqUZK1AVifGaaLyay663C9VfS6-svDH4fipVH612IDnFcBg5Z7wWJtWqbHhhKBM0VblqKtT6tIm2rBfQaCxGr9yO6O5Ka2dy6i-lqIqMVyUKvNsI9P73EkKUCxs0OKda8MubfWcFY5Sxh6CUZzmvOKJv_kPvL8SGmirM1bbG4xb1SlQeihxTpxlbpTi8h8KrgYXV2LzGon3H4f2OAzIRruJULUOQ44vJw9nzn7vs2y12BsphW3m3XHVd2AXFGtS9D6EHc3cejMrV7N1WQ65mT25mD91ebZ_lndPtsPF_CNooMw</recordid><startdate>20160805</startdate><enddate>20160805</enddate><creator>King, Anthony P</creator><creator>Muzik, Maria</creator><creator>Hamilton, Lindsay</creator><creator>Taylor, Alexander B</creator><creator>Rosenblum, Katherine L</creator><creator>Liberzon, Israel</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160805</creationdate><title>Dopamine Receptor Gene DRD4 7-Repeat Allele X Maternal Sensitivity Interaction on Child Externalizing Behavior Problems: Independent Replication of Effects at 18 Months</title><author>King, Anthony P ; Muzik, Maria ; Hamilton, Lindsay ; Taylor, Alexander B ; Rosenblum, Katherine L ; Liberzon, Israel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-ad0e2ea0b477fe51186c09bf06429bbcf038403288f9963b97d001bad192844d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>African Americans - genetics</topic><topic>Age</topic><topic>Alleles</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Babies</topic><topic>Behavior</topic><topic>Behavior problems</topic><topic>Biology and Life Sciences</topic><topic>Child behavior</topic><topic>Child Behavior Disorders - genetics</topic><topic>Children &amp; youth</topic><topic>Cohort Studies</topic><topic>Depression</topic><topic>Dopamine</topic><topic>Dopamine D4 receptors</topic><topic>Dopamine receptors</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Genotypes</topic><topic>Humans</topic><topic>Infant</topic><topic>Infants</topic><topic>Longitudinal Studies</topic><topic>Maternal behavior</topic><topic>Maternal Behavior - psychology</topic><topic>Medical screening</topic><topic>Medicine and Health Sciences</topic><topic>Mental depression</topic><topic>Minisatellite Repeats</topic><topic>Mother-Child Relations</topic><topic>Mothers - psychology</topic><topic>People and Places</topic><topic>Physical Sciences</topic><topic>Preschool children</topic><topic>Psychiatry</topic><topic>Receptors, Dopamine D4 - genetics</topic><topic>Regression analysis</topic><topic>Research and Analysis Methods</topic><topic>Sensitivity</topic><topic>Sensitivity analysis</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, Anthony P</creatorcontrib><creatorcontrib>Muzik, Maria</creatorcontrib><creatorcontrib>Hamilton, Lindsay</creatorcontrib><creatorcontrib>Taylor, Alexander B</creatorcontrib><creatorcontrib>Rosenblum, Katherine L</creatorcontrib><creatorcontrib>Liberzon, Israel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, Anthony P</au><au>Muzik, Maria</au><au>Hamilton, Lindsay</au><au>Taylor, Alexander B</au><au>Rosenblum, Katherine L</au><au>Liberzon, Israel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopamine Receptor Gene DRD4 7-Repeat Allele X Maternal Sensitivity Interaction on Child Externalizing Behavior Problems: Independent Replication of Effects at 18 Months</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-08-05</date><risdate>2016</risdate><volume>11</volume><issue>8</issue><spage>e0160473</spage><epage>e0160473</epage><pages>e0160473-e0160473</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Competing Interests: The authors have declared that no competing interests exist.</notes><notes>Conceived and designed the experiments: AK MM KR LH IL.Performed the experiments: AK AT.Analyzed the data: AK MM LH KR.Contributed reagents/materials/analysis tools: AK MM IL.Wrote the paper: AK MM LH KR IL.</notes><notes>These authors are co-first authors on this work.</notes><abstract>The DRD4 VNTR has been associated with child behavior problems in interaction with maternal insensitivity in European and American cohorts of preschoolers, with the 7-repeat (7R) allele associated with greater problems. We sought to replicate and expand these findings by examining effects on reports of child behavior problems at 18 months. A 63 family sample with data for observed maternal sensitivity ratings, DRD4 VNTR genotype, and maternal report of child behavior problems at 18-months was used in this preliminary analysis. Maternal sensitivity was measured at 6-months of age using laboratory observational measures (free-play and a teaching task). Maternal report of toddler behavior was obtained at 18-months via the standard Child Behavior Checklist, and infant genotype on the DRD4 VNTR was obtained using PCR. Infants carrying the DRD4 7R allele showed greater effects of maternal insensitivity than non-carriers for behavioral problems at 18-months. We replicated previous findings of association of infant DRD4 x maternal sensitivity interactions with child Externalizing problems in the European-ancestry sample (N = 42) in a median split of maternal sensitivity (p = .00011, eta2 = .329) and in regression analyses controlling for maternal age, maternal depression, and child gender in European ancestry (B = -3.4, SE 1.33, p = .01) and the total sample (B = -2.2, SE 1.02, p = .02). Exploratory analyses also found evidence of DRD4 x maternal sensitivity interaction with the CBCL ADHD scale. These findings replicate in an independent cohort DRD4 x maternal insensitivity interaction effect on child externalizing behavior problems at 18 months, further supporting the role of the DRD4 genotype in differential sensitivity to parenting.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27494520</pmid><doi>10.1371/journal.pone.0160473</doi><tpages>e0160473</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2016-08, Vol.11 (8), p.e0160473-e0160473
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1812517477
source Open Access: PubMed Central; Publicly Available Content Database
subjects African Americans - genetics
Age
Alleles
Attention deficit hyperactivity disorder
Babies
Behavior
Behavior problems
Biology and Life Sciences
Child behavior
Child Behavior Disorders - genetics
Children & youth
Cohort Studies
Depression
Dopamine
Dopamine D4 receptors
Dopamine receptors
European Continental Ancestry Group - genetics
Female
Genetic aspects
Genotypes
Humans
Infant
Infants
Longitudinal Studies
Maternal behavior
Maternal Behavior - psychology
Medical screening
Medicine and Health Sciences
Mental depression
Minisatellite Repeats
Mother-Child Relations
Mothers - psychology
People and Places
Physical Sciences
Preschool children
Psychiatry
Receptors, Dopamine D4 - genetics
Regression analysis
Research and Analysis Methods
Sensitivity
Sensitivity analysis
Studies
title Dopamine Receptor Gene DRD4 7-Repeat Allele X Maternal Sensitivity Interaction on Child Externalizing Behavior Problems: Independent Replication of Effects at 18 Months
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-11-02T20%3A15%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dopamine%20Receptor%20Gene%20DRD4%207-Repeat%20Allele%20X%20Maternal%20Sensitivity%20Interaction%20on%20Child%20Externalizing%20Behavior%20Problems:%20Independent%20Replication%20of%20Effects%20at%2018%20Months&rft.jtitle=PloS%20one&rft.au=King,%20Anthony%20P&rft.date=2016-08-05&rft.volume=11&rft.issue=8&rft.spage=e0160473&rft.epage=e0160473&rft.pages=e0160473-e0160473&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0160473&rft_dat=%3Cgale_plos_%3EA460030519%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c725t-ad0e2ea0b477fe51186c09bf06429bbcf038403288f9963b97d001bad192844d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1812517477&rft_id=info:pmid/27494520&rft_galeid=A460030519&rfr_iscdi=true