Significance of Epicardial and Intrathoracic Adipose Tissue Volume among Type 1 Diabetes Patients in the DCCT/EDIC: A Pilot Study

Type 1 diabetes (T1DM) patients are at increased risk of coronary artery disease (CAD). This pilot study sought to evaluate the relationship between epicardial adipose tissue (EAT) and intra-thoracic adipose tissue (IAT) volumes and cardio-metabolic risk factors in T1DM. EAT/IAT volumes in 100 patie...

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Bibliographic Details
Published in:PloS one 2016-07, Vol.11 (7), p.e0159958-e0159958
Main Authors: Darabian, Sirous, Backlund, Jye-Yu C, Cleary, Patricia A, Sheidaee, Nasim, Bebu, Ionut, Lachin, John M, Budoff, Matthew J
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - diagnostic imaging
Adult
Age
Biology and Life Sciences
Biomedical research
Body fat
Body mass
Body mass index
Cardiovascular disease
Care and treatment
Chronic kidney failure
Complications
Complications and side effects
Computed tomography
Coronary artery
Coronary artery disease
Coronary vessels
Correlation
Correlation analysis
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - diagnostic imaging
Diabetic Cardiomyopathies - epidemiology
Drug stores
Epidemiology
Excretion
Family medical history
Female
Gender differences
Glucose
Health risk assessment
Health risks
Heart attacks
Heart diseases
Hemoglobin
Hemoglobin A - metabolism
Hip
Humans
Insulin
Lipids
Male
Medical imaging
Medicine and Health Sciences
Metabolism
Middle Aged
Mortality
Obesity
Patients
Pericardium - diagnostic imaging
Physiological aspects
Pilot Projects
Regression analysis
Regression models
Research and Analysis Methods
Risk analysis
Risk factors
Statistical analysis
Thoracic Cavity - diagnostic imaging
Thorax
Tomography
Triglycerides - blood
Tumor necrosis factor-TNF
Type 1 diabetes
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Summary:Type 1 diabetes (T1DM) patients are at increased risk of coronary artery disease (CAD). This pilot study sought to evaluate the relationship between epicardial adipose tissue (EAT) and intra-thoracic adipose tissue (IAT) volumes and cardio-metabolic risk factors in T1DM. EAT/IAT volumes in 100 patients, underwent non-contrast cardiac computed tomography in the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were measured by a certified reader. Fat was defined as pixels' density of -30 to -190 Hounsfield Unit. The associations were assessed using-Pearson partial correlation and linear regression models adjusted for gender and age with inverse probability sample weighting. The weighted mean age was 43 years (range 32-57) and 53% were male. Adjusted for gender, Pearson correlation analysis showed a significant correlation between age and EAT/IAT volumes (both p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0159958