The Multifocal On- and Off-Responses in the Human Diabetic Retina

The characteristics of the on- and off-responses in the human diabetic retina by a "long-duration" multifocal electroretinogram (mfERG) paradigm were investigated. Changes in the retinal antagonistic interaction were also evaluated in the early stage of diabetes mellitus (DM). Twenty type...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2016-05, Vol.11 (5), p.e0155071-e0155071
Main Authors: Lung, Jenny C Y, Swann, Peter G, Chan, Henry H L
Format: Article
Language:English
Subjects:
Adult
Amplitudes
Analysis of Variance
Antagonism
Apoptosis
Automation
Biology and Life Sciences
Biomarkers
Blood Glucose
Crosstalk
Development and progression
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Diabetic retinopathy
Diabetic Retinopathy - diagnosis
Diabetic Retinopathy - physiopathology
Diabetics
Diagnosis
Diseases
Electroretinography
Female
Human behavior
Humans
Insulin
Laboratories
Male
Medicine and Health Sciences
Middle Aged
Neurosciences
Optometry
Patients
Photic Stimulation
Physical Sciences
Reaction Time
Retina
Retina - physiopathology
Retinopathy
Risk factors
Social Sciences
Stimulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The characteristics of the on- and off-responses in the human diabetic retina by a "long-duration" multifocal electroretinogram (mfERG) paradigm were investigated. Changes in the retinal antagonistic interaction were also evaluated in the early stage of diabetes mellitus (DM). Twenty type II diabetic patients with no or mild non-proliferative diabetic retinopathy (NPDR) and twenty-one age-matched healthy controls were recruited for "long-duration" mfERG measurements. A 61-hexagon mfERG stimulus was displayed under two chromatic conditions (white/black and blue/black) at matched luminance. The amplitudes and implicit times of the on-response components (N1, P1 and N2) and off-response (P2) components were analysed. The blue stimulation generally triggered greater mfERG amplitudes in P1, N2 and P2 (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0155071