Prospective Study for Comparison of Endoscopic Ultrasound-Guided Tissue Acquisition Using 25- and 22-Gauge Core Biopsy Needles in Solid Pancreatic Masses

Although thicker needles theoretically allow more tissue to be collected, their decreased flexibility can cause mechanical damage to the endoscope, technical failure, and sample blood contamination. The effects of needle gauge on diagnostic outcomes of endoscopic ultrasound-guided fine-needle biopsy...

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Bibliographic Details
Published in:PloS one 2016-05, Vol.11 (5), p.e0154401-e0154401
Main Authors: Park, Se Woo, Chung, Moon Jae, Lee, Sang Hoon, Lee, Hee Seung, Lee, Hyun Jik, Park, Jeong Yup, Park, Seung Woo, Song, Si Young, Kim, Hoguen, Chung, Jae Bock, Bang, Seungmin
Format: Article
Language:English
Subjects:
Accuracy
Adult
Aged
Aged, 80 and over
Anesthesia
Biology and Life Sciences
Biopsy
Care and treatment
Clinical trials
Contamination
Cores
Diagnostic systems
Endoscopes
Endoscopic Ultrasound-Guided Fine Needle Aspiration - instrumentation
Endoscopy
Female
Gastroenterology
Hospitals
Humans
Hypodermic needles
Internal medicine
Lesions
Male
Medical diagnosis
Medicine
Medicine and Health Sciences
Middle Aged
Needle biopsy
Needles
Pancreas
Pancreas - pathology
Pancreatic cancer
Pancreatic tumors
Pathologists
Patients
Physicians
Practice
Procurement
Prospective Studies
Research and Analysis Methods
Social Sciences
Statistical analysis
Suction
Tumors
Ultrasonic imaging
Ultrasound
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Description
Summary:Although thicker needles theoretically allow more tissue to be collected, their decreased flexibility can cause mechanical damage to the endoscope, technical failure, and sample blood contamination. The effects of needle gauge on diagnostic outcomes of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) of pancreatic mass lesions remain unknown. This study compared procurement rates of histologic cores obtained from EUS-FNB of pancreatic masses using 25- and 22-gauge core biopsy needles. From March 2014 to July 2014, 66 patients with solid pancreatic mass underwent EUS-FNB with both 25- and 22-gauge core biopsy needles. Among them, 10 patients were excluded and thus 56 patients were eligible for the analyses. Needle sequences were randomly assigned, and two passes were made with each needle, consisting of 10 uniform to-and-fro movements on each pass with 10 mL syringe suction. A pathologist blinded to needle sequence evaluated specimens for the presence of histologic core. The mean patient age was 65.8 ± 9.5 years (range, 44-89 years); 35 patients (62.5%) were men. The mean pancreatic mass size was 35.3 ± 17.1 mm (range 14-122.3 mm). Twenty-eight patients (50%) had tumors at the pancreas head or uncinate process. There were no significant differences in procurement rates of histologic cores between 25-gauge (49/56, 87.5%) and 22-gauge (46/56, 82.1%, P = 0.581) needles or diagnostic accuracy using only histologic cores (98% and 95%). There were no technical failures or procedure-related adverse events. The 25-gauge core biopsy needle could offer acceptable and comparable outcomes regarding diagnostic performance including histologic core procurement rates compared to the 22-gauge core biopsy needle, although the differences were not statistically significant. ClinicalTrials.gov NCT01795066.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0154401