Quantitative Susceptibility Mapping-Based Microscopy of Magnetic Resonance Venography (QSM-mMRV) for In Vivo Morphologically and Functionally Assessing Cerebromicrovasculature in Rat Stroke Model

Abnormal cerebral oxygenation and vessel structure is a crucial feature of stroke. An imaging method with structural and functional information is necessary for diagnosis of stroke. This study applies QSM-mMRV (quantitative susceptibility mapping-based microscopic magnetic resonance venography) for...

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Bibliographic Details
Published in:PloS one 2016-03, Vol.11 (3), p.e0149602-e0149602
Main Authors: Hsieh, Meng-Chi, Tsai, Ching-Yi, Liao, Min-Chiao, Yang, Jenq-Lin, Su, Chia-Hao, Chen, Jyh-Horng
Format: Article
Language:English
Subjects:
Analysis
Animals
Bioinformatics
Biology and Life Sciences
Blood
Blood vessels
Brain
Brain research
Cerebrovascular Circulation
Cerebrovascular diseases
Disease Models, Animal
Electrical engineering
Gene mapping
Hospitals
Magnetic permeability
Magnetic resonance
Magnetic Resonance Angiography - methods
Magnetic resonance imaging
Male
Mapping
Mathematical models
Medical imaging
Medicine and Health Sciences
Microcirculation
Microscopy
Microvasculature
Monitoring
Neuroimaging
Neurosciences
NMR
Nuclear magnetic resonance
Oximetry - methods
Oxygen
Oxygen - administration & dosage
Oxygen - blood
Oxygen content
Oxygenation
Phlebography
Physical Sciences
Quantitative genetics
Rats
Rats, Sprague-Dawley
Reperfusion
Research and Analysis Methods
Resonance
Saturation
Stroke
Stroke - blood
Stroke - diagnostic imaging
Stroke - physiopathology
Structure-function relationships
Studies
Vascular diseases
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Summary:Abnormal cerebral oxygenation and vessel structure is a crucial feature of stroke. An imaging method with structural and functional information is necessary for diagnosis of stroke. This study applies QSM-mMRV (quantitative susceptibility mapping-based microscopic magnetic resonance venography) for noninvasively detecting small cerebral venous vessels in rat stroke model. First, susceptibility mapping is optimized and calculated from magnetic resonance (MR) phase images of a rat brain. Subsequently, QSM-mMRV is used to simultaneously provide information on microvascular architecture and venous oxygen saturation (SvO2), both of which can be used to evaluate the physiological and functional characteristics of microvascular changes for longitudinally monitoring and therapeutically evaluating a disease model. Morphologically, the quantification of vessel sizes using QSM-mMRV was 30% smaller than that of susceptibility-weighted imaging (SWI), which eliminated the overestimation of conventional SWI. Functionally, QSM-mMRV estimated an average SvO2 ranging from 73% to 85% for healthy rats. Finally, we also applied QSM to monitor the revascularization of post-stroke vessels from 3 to 10 days after reperfusion. QSM estimations of SvO2 were comparable to those calculated using the pulse oximeter standard metric. We conclude that QSM-mMRV is useful for longitudinally monitoring blood oxygen and might become clinically useful for assessing cerebrovascular diseases.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0149602