Alcohol Consumption-Related Metabolites in Relation to Colorectal Cancer and Adenoma: Two Case-Control Studies Using Serum Biomarkers

Alcohol is a known carcinogen that may be associated with colorectal cancer. However, most epidemiologic studies assess alcoholic beverage consumption using self-reported data, leading to potential exposure misclassification. Biomarkers of alcohol consumption may provide an alternative, complementar...

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Published in:	PloS one 2016-03, Vol.11 (3), p.e0150962
Main Authors:	Troche, Jose Ramon, Mayne, Susan T, Freedman, Neal D, Shebl, Fatma M, Guertin, Kristin A, Cross, Amanda J, Abnet, Christian C
Format:	Article
Language:	eng
Subjects:	Adenoma Adenoma - blood Adults Aged Alcohol Drinking - adverse effects Alcohol use Alcoholic beverages Alcoholic Beverages - adverse effects Analysis Androstane-3,17-diol - analogs & derivatives Androstane-3,17-diol - blood Bilirubin Bilirubin - blood Biology and Life Sciences Biomarkers Biomarkers - blood Cancer Cancer screening Carcinogens Case-Control Studies Colon Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - blood Confidence intervals Dipeptides - blood Drinking (Alcoholic beverages) Drinking of alcoholic beverages Epidemiology Ethanol - metabolism Fatty Acids, Monounsaturated - blood Female Food Glucuronates - blood Health aspects Health risk assessment Humans Linoleic Acid - blood Lung cancer Male Medical research Medical screening Medicine and Health Sciences Metabolism Metabolites Metabolomics Middle Aged Multivariable control Nutrition research Odds Ratio Ovarian cancer Ovarian carcinoma Palmitic Acids - blood Peptides, Cyclic - blood Physiological aspects Prostate Public health Regression analysis Regression models Risk factors Smoking Statistical analysis Studies Tobacco Tumors Womens health
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Summary:	Alcohol is a known carcinogen that may be associated with colorectal cancer. However, most epidemiologic studies assess alcoholic beverage consumption using self-reported data, leading to potential exposure misclassification. Biomarkers of alcohol consumption may provide an alternative, complementary approach that reduces misclassification and incorporates individual differences in alcohol metabolism. Therefore, we evaluated the relationship between previously identified alcohol consumption-related metabolites and colorectal cancer and adenoma using serum metabolomics data from two studies. Data on colorectal cancer were obtained from a nested case-control study of 502 US adults (252 cases, 250 controls) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Data on colorectal adenoma were obtained from a case-control study of 197 US adults (120 cases, 77 controls) from the Navy Colon Adenoma Study. Unconditional multivariable logistic regression models were fit to calculate odds ratios (OR) and 95% confidence intervals (CI) for eight alcohol consumption-related metabolites identified in a previous analysis: ethyl glucuronide; 4-androstene-3beta,17beta-diol disulfate 1; 5-alpha-androstan-3beta,17beta-diol disulfate; 16-hydroxypalmitate; bilirubin (E,Z or Z,E); cyclo (-leu-pro); dihomo-linoleate (20:2n6); and palmitoleate (16:1n7). We found no clear association between these alcohol consumption-related metabolites and either endpoint. However, we did observe an inverse association between cyclo (-leu-pro) and colorectal adenoma that was only observed in the highest metabolite quantile (OR 4th vs. 1st Quantile = 0.30, 95% CI: 0.12-0.78; P-trend = 0.047), but no association for colorectal cancer. In conclusion, there were no adverse associations between alcohol consumption-related metabolites and colorectal cancer or adenoma.
ISSN:	1932-6203 1932-6203