Circulating S100A12 Levels Are Associated with Progression of Abdominal Aortic Calcification in Hemodialysis Patients

Vascular calcification is an important factor associated with mortality in dialysis patients. Recently, soluble receptor for advanced glycation end product (sRAGE) and extracellular RAGE binding protein S100A12 (EN-RAGE) have been reported to be involved in the process of vascular calcification. The...

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Bibliographic Details
Published in:PloS one 2016-02, Vol.11 (2), p.e0150145-e0150145
Main Authors: Choi, Byoung Ho, Ro, Han, Jung, Eul Sik, Kim, Ae Jin, Chang, Jae Hyun, Lee, Hyun Hee, Chung, Wookyung, Jung, Ji Yong
Format: Article
Language:English
Subjects:
Advanced glycation end products
Advanced glycosylation end products
Aorta
Aorta, Abdominal - diagnostic imaging
Aorta, Abdominal - physiopathology
Atherosclerosis
Binding proteins
Biology and Life Sciences
Biomarkers - blood
Calcification
Calcification (ectopic)
Calcification (Physiology)
Comparative analysis
Confidence intervals
Cytokines
Diabetes
Diabetes mellitus
Diagnosis
Dialysis
Disease Progression
Female
Genetic aspects
Glycosylation
Health aspects
Heart attacks
Hemodialysis
Humans
Internal medicine
Kidney diseases
Laboratories
Ligands
Male
Medicine
Medicine and Health Sciences
Middle Aged
Mortality
Nephrology
Patients
Physical Sciences
Physiological aspects
Proteins
Radiography
Receptor for Advanced Glycation End Products - blood
Renal Dialysis - adverse effects
Research and Analysis Methods
Risk Factors
S100A12 Protein - blood
Serum levels
Spine
Spine (lumbar)
Statistical analysis
Vascular Calcification - blood
Vascular Calcification - diagnostic imaging
Vascular Calcification - physiopathology
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Summary:Vascular calcification is an important factor associated with mortality in dialysis patients. Recently, soluble receptor for advanced glycation end product (sRAGE) and extracellular RAGE binding protein S100A12 (EN-RAGE) have been reported to be involved in the process of vascular calcification. Therefore, we investigated whether sRAGE and S100A12 are useful indicators of progression of abdominal aortic calcification in hemodialysis (HD) patients. We analyzed annual changes in vascular calcification score (VCS) for up to 4 years, compared to clinical and biological parameters in 149 HD patients. VCS was assessed annually using plain X-ray images of the lateral lumbar spine. The progression group was defined as patients with an increase in VCS more than 1 point each year on average during the observation period. Time-averaged concentrations were also evaluated to examine the association between biological parameters and changes in VCS. The patients had a mean age of 58.59 ± 12.93 years; 53.7% were male, and 45% were diabetic. The VCS increased in 55 patients; the mean increase was 1.60 ± 2.91 points. In a stepwise multivariate logistic analysis, we found that higher levels of S100A12 were significantly associated with progression of VCS (odds ratio [OR], 2.622; 95% confidence interval [CI], 1.371-5.016; P = 0.004). The relationship between sRAGE and VCS was not statistically significant (OR, 0.644; 95% CI, 0.302-1.374; P = 0.255). Our findings suggest that serum levels of S100A12 are associated with progression of abdominal aortic calcification in HD patients, independent of sRAGE level.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0150145