Phenolic Compounds in Extra Virgin Olive Oil Stimulate Human Osteoblastic Cell Proliferation

In this study, we aimed to clarify the effects of phenolic compounds and extracts from different extra virgin olive oil (EVOO) varieties obtained from fruits of different ripening stages on osteoblast cells (MG-63) proliferation. Cell proliferation was increased by hydroxytyrosol, luteolin, apigenin...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2016-03, Vol.11 (3), p.e0150045-e0150045
Main Authors: García-Martínez, Olga, De Luna-Bertos, Elvira, Ramos-Torrecillas, Javier, Ruiz, Concepción, Milia, Egle, Lorenzo, María Luisa, Jimenez, Brigida, Sánchez-Ortiz, Araceli, Rivas, Ana
Format: Article
Language:English
Subjects:
Acids
Agriculture
Analysis
Analysis of Variance
Apigenin - pharmacology
Biocompatibility
Biology and Life Sciences
Bone cancer
Caffeic Acids - pharmacology
Cell growth
Cell Line, Tumor
Cell proliferation
Cell Proliferation - drug effects
Chromatography, High Pressure Liquid - methods
Coumaric Acids - pharmacology
Dose-Response Relationship, Drug
Drug therapy
Fisheries
Food science
Fruit - chemistry
Fruits
Geriatrics
Health sciences
Humans
Luteolin - pharmacology
Mass Spectrometry - methods
Medicine and Health Sciences
Metabolism
Nutrition
Oils & fats
Older people
Olea - chemistry
Olea - growth & development
Oleuropein
Olive oil
Olive Oil - chemistry
Olive Oil - isolation & purification
Osteoblasts
Osteoblasts - drug effects
Osteoblasts - pathology
Osteoporosis
Pharmacy
Phenolic compounds
Phenols
Phenols - analysis
Phenols - pharmacology
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - pharmacology
Physical Sciences
Polyphenols
Principal Component Analysis
Research and Analysis Methods
Ripening
Sarcoma
Signaling
Studies
Time Factors
Training
Vanillic acid
Vanillin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, we aimed to clarify the effects of phenolic compounds and extracts from different extra virgin olive oil (EVOO) varieties obtained from fruits of different ripening stages on osteoblast cells (MG-63) proliferation. Cell proliferation was increased by hydroxytyrosol, luteolin, apigenin, p-coumaric, caffeic, and ferulic acids by approximately 11-16%, as compared with controls that were treated with one vehicle alone, while (+)-pinoresinol, oleuropein, sinapic, vanillic acid and derivative (vanillin) did not affect cell proliferation. All phenolic extracts stimulated MG-63 cell growth, and they induced higher cell proliferation rates than individual compounds. The most effective EVOO phenolic extracts were those obtained from the Picual variety, as they significantly increased cell proliferation by 18-22%. Conversely, Arbequina phenolic extracts increased cell proliferation by 9-13%. A decline in osteoblast proliferation was observed in oils obtained from olive fruits collected at the end of the harvest period, as their total phenolic content decreases at this late stage. Further research on the signaling pathways of olive oil phenolic compounds involved in the processes and their metabolism should be carried out to develop new interventions and adjuvant therapies using EVOO for bone health (i.e.osteoporosis) in adulthood and the elderly.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0150045