C-Reactive Protein and Hemogram Parameters for the Non-Sepsis Systemic Inflammatory Response Syndrome and Sepsis: What Do They Mean?

Sepsis is one of the most common reasons of increased mortality and morbidity in the intensive care unit. The changes in CRP levels and hemogram parameters and their combinations may help to distinguish sepsis from non-sepsis SIRS. The aim of this study is to investigate the CRP and hemogram paramet...

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Bibliographic Details
Published in:PloS one 2016-02, Vol.11 (2), p.e0148699-e0148699
Main Authors: Gucyetmez, Bulent, Atalan, Hakan K
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
APACHE
Biology and Life Sciences
Biomarkers
Blood
Body Fluids - microbiology
C-reactive protein
C-Reactive Protein - analysis
Corticosteroids
Demographics
Development and progression
Diagnosis, Differential
Elective Surgical Procedures - statistics & numerical data
Emergencies
ErbB-2 protein
Female
Flow cytometry
Genetic aspects
Gram-positive bacteria
Health aspects
Heart rate
Hematology
Hospital Mortality
Hospitals
Humans
Immunosuppressive agents
Infections
Inflammation
Inflammatory response
Intensive care
Intensive Care Units - statistics & numerical data
Laboratories
Length of Stay - statistics & numerical data
Leukocyte Count
Lymphocytes
Male
Mean Platelet Volume
Measurement
Medical diagnosis
Medicine and Health Sciences
Microorganisms
Middle Aged
Morbidity
Mortality
Multivariate analysis
Neutrophils
Patients
Physiological aspects
Physiology
Platelet Count
Proteins
Retrospective Studies
Sepsis
Sepsis - blood
Sepsis - diagnosis
Severity of Illness Index
Systemic inflammatory response syndrome
Systemic Inflammatory Response Syndrome - blood
Systemic Inflammatory Response Syndrome - diagnosis
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Summary:Sepsis is one of the most common reasons of increased mortality and morbidity in the intensive care unit. The changes in CRP levels and hemogram parameters and their combinations may help to distinguish sepsis from non-sepsis SIRS. The aim of this study is to investigate the CRP and hemogram parameters as an indicator of sepsis. A total of 2777 patients admitted to the ICU of two centers between 2006-2013 were evaluated retrospectively. The patients were diagnosed as SIRS (-), non-sepsis SIRS and sepsis. The patients who were under 18 years old, re-admitted, diagnosed with hematological disease, on corticosteroid and immunosuppressive therapy, SIRS (-), culture negative, undocumented laboratory values and outcomes were excluded. 1257 patients were divided into 2 groups as non-sepsis SIRS and sepsis. The patients' demographic data, CRP levels, hemogram parameters, length of ICU stay and mortality were recorded. 1257 patients were categorized as non-sepsis SIRS (816, 64.9%) and sepsis (441, 35.1%). In the multivariate analysis, the likelihood of sepsis was increased 3.2 (2.2-4.6), 1.7 (1.2-2.4), 1.6 (1.2-2.1), 2.3 (1.4-3.8), 1.5 (1.1-2.1) times by the APACHE II≥13, SOFA score≥4, CRP≥4.0, LymC
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0148699