Gender Specific Association of Serum Leptin and Insulinemic Indices with Nonalcoholic Fatty Liver Disease in Prediabetic Subjects

Adipose tissue-derived hormone leptin plays a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity which also represent the risk factors for nonalcoholic fatty liver disease (NAFLD). The present study explored the gender specific association of serum...

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Bibliographic Details
Published in:PloS one 2015-11, Vol.10 (11), p.e0142165-e0142165
Main Authors: Hossain, Israt Ara, Akter, Salima, Rahman, Mohammad Khalilur, Ali, Liaquat
Format: Article
Language:English
Subjects:
Adipose tissue
Adiposity
Adult
Aged
Anthropometry
Bangladesh
Biochemistry
Biology
Body mass
Body Mass Index
Body size
Care and treatment
Cholesterol
Correlation
Cross-Sectional Studies
Development and progression
Diabetes
Fasting
Fatty acids
Fatty liver
Female
Gender
Glucose
Glucose tolerance
Health risks
Health sciences
Hepatology
Homeostasis
Humans
Infrared radiation
Insulin
Insulin - blood
Insulin - metabolism
Insulin resistance
Insulin Secretion
Leptin
Leptin - blood
Linear Models
Lipids
Liver
Liver diseases
Male
Metabolic syndrome
Middle Aged
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - complications
Obesity
Pathogenesis
Patient outcomes
Plasma
Postprandial Period
Prediabetic state
Prediabetic State - blood
Prediabetic State - complications
Prediabetic State - diagnostic imaging
Regression analysis
Risk analysis
Risk Factors
Rodents
Secretion
Sensitivity
Sensitivity analysis
Sex Factors
Triglycerides - blood
Ultrasonic imaging
Ultrasonography
Ultrasound
Womens health
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Summary:Adipose tissue-derived hormone leptin plays a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity which also represent the risk factors for nonalcoholic fatty liver disease (NAFLD). The present study explored the gender specific association of serum leptin and insulinemic indices with NAFLD in Bangladeshi prediabetic subjects. Under a cross-sectional analytical design a total of 110 ultrasound examined prediabetic subjects, aged 25-68 years consisting of 57.3% male (55.6% non NAFLD and 44.4% NAFLD) and 42.7% female (57.4% non NAFLD and 42.6% NAFLD), were investigated. Insulin secretory function (HOMA%B) and insulin sensitivity (HOMA%S) were calculated from homeostasis model assessment (HOMA). Serum leptin showed significant positive correlation with fasting insulin (r = 0.530, P = 0.004), postprandial insulin (r = 0.384, P = 0.042) and HOMA-IR (r = 0.541, P = 0.003) as well as significant negative correlation with HOMA%S (r = -0.388, P = 0.046) and HOMA%B (r = -0.356, P = 0.039) in male prediabetic subjects with NAFLD. In multiple linear regression analysis, log transformed leptin showed significant positive association with HOMA-IR (β = 0.706, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0142165