Beyond the Whole-Genome Duplication: Phylogenetic Evidence for an Ancient Interspecies Hybridization in the Baker's Yeast Lineage

Whole-genome duplications have shaped the genomes of several vertebrate, plant, and fungal lineages. Earlier studies have focused on establishing when these events occurred and on elucidating their functional and evolutionary consequences, but we still lack sufficient understanding of how genome dup...

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Bibliographic Details
Published in:PLoS biology 2015-08, Vol.13 (8), p.e1002220
Main Authors: Marcet Houben, Marina, Gabaldón Estevan, Juan Antonio, 1973
Format: Article
Language:English
Subjects:
Advantages
Evolution
Evolution, Molecular
Gene Duplication
Genes
Genome, Fungal
Genomes
Hybridization
Hybridization, Genetic
Metabolisme
Mutation
Phylogenetics
Phylogeny
Proteome - genetics
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Vertebrates
Yeast
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Summary:Whole-genome duplications have shaped the genomes of several vertebrate, plant, and fungal lineages. Earlier studies have focused on establishing when these events occurred and on elucidating their functional and evolutionary consequences, but we still lack sufficient understanding of how genome duplications first originated. We used phylogenomics to study the ancient genome duplication occurred in the yeast Saccharomyces cerevisiae lineage and found compelling evidence for the existence of a contemporaneous interspecies hybridization. We propose that the genome doubling was a direct consequence of this hybridization and that it served to provide stability to the recently formed allopolyploid. This scenario provides a mechanism for the origin of this ancient duplication and the lineage that originated from it and brings a new perspective to the interpretation of the origin and consequences of whole-genome duplications.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.1002220