Functional Brain Dysfunction in Patients with Benign Childhood Epilepsy as Revealed by Graph Theory

There is growing evidence that brain networks are altered in epileptic subjects. In this study, we investigated the functional connectivity and brain network properties of benign childhood epilepsy with centrotemporal spikes using graph theory. Benign childhood epilepsy with centrotemporal spikes is...

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Bibliographic Details
Published in:PloS one 2015-10, Vol.10 (10), p.e0139228-e0139228
Main Authors: Adebimpe, Azeez, Aarabi, Ardalan, Bourel-Ponchel, Emilie, Mahmoudzadeh, Mahdi, Wallois, Fabrice
Format: Article
Language:English
Subjects:
Action Potentials
Adolescent
Benign
Brain
Brain - physiopathology
Brain diseases
Case-Control Studies
Child
Children
Clustering
Complications and side effects
Data processing
EEG
Epilepsy
Epilepsy - physiopathology
Frequencies
Frequency dependence
Genetic aspects
Graph theory
Humans
Life Sciences
Localization
Mathematical analysis
Models, Theoretical
Neural networks
Neurons and Cognition
Patients
Pediatric epilepsy
Prognosis
Risk factors
Spikes
Studies
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Summary:There is growing evidence that brain networks are altered in epileptic subjects. In this study, we investigated the functional connectivity and brain network properties of benign childhood epilepsy with centrotemporal spikes using graph theory. Benign childhood epilepsy with centrotemporal spikes is the most common form of idiopathic epilepsy in young children under the age of 16 years. High-density EEG data were recorded from patients and controls in resting state with eyes closed. Data were preprocessed and spike and spike-free segments were selected for analysis. Phase locking value was calculated for all paired combinations of channels and for five frequency bands (δ, θ, α, β1 and β2). We computed the degree and small-world parameters--clustering coefficient (C) and path length (L)--and compared the two patient conditions to controls. A higher degree at epileptic zones during interictal epileptic spikes (IES) was observed in all frequency bands. Both patient conditions reduced connection at the occipital and right frontal regions close to the epileptic zone in the α band. The "small-world" features (high C and short L) were deviated in patients compared to controls. A changed from an ordered network in the δ band to a more randomly organized network in the α band was observed in patients compared to healthy controls. These findings show that the benign epileptic brain network is disrupted not only at the epileptic zone, but also in other brain regions especially frontal regions.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0139228