Evaluation of LiF:Mg,Ti (TLD-100) for Intraoperative Electron Radiation Therapy Quality Assurance

Purpose of the present work was to investigate thermoluminescent dosimeters (TLDs) response to intraoperative electron radiation therapy (IOERT) beams. In an IOERT treatment, a large single radiation dose is delivered with a high dose-per-pulse electron beam (2-12 cGy/pulse) during surgery. To verif...

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Bibliographic Details
Published in:PloS one 2015-10, Vol.10 (10), p.e0139287
Main Authors: Liuzzi, Raffaele, Savino, Federica, D'Avino, Vittoria, Pugliese, Mariagabriella, Cella, Laura
Format: Article
Language:English
Subjects:
Analysis
Background radiation
Brachytherapy - methods
Breast cancer
Calibration
Cancer therapies
Councils
Dosimeters
Dosimetry
Drug dosages
Electron beams
Electron radiation
Electrons
Fluorides - chemistry
Health aspects
Humans
In vivo methods and tests
Irradiated
Lithium Compounds - chemistry
Lithium fluoride
Magnesium - chemistry
Medical research
Medicine
Methods
Monte Carlo Method
Oncology
Photon beams
Physics
Quality assurance
Quality Control
Radiation
Radiation dosage
Radiation therapy
Radiotherapy
Regression analysis
Surgery
Thermoluminescence
Thermoluminescent Dosimetry - instrumentation
Thermoluminescent Dosimetry - methods
Titanium - chemistry
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Summary:Purpose of the present work was to investigate thermoluminescent dosimeters (TLDs) response to intraoperative electron radiation therapy (IOERT) beams. In an IOERT treatment, a large single radiation dose is delivered with a high dose-per-pulse electron beam (2-12 cGy/pulse) during surgery. To verify and to record the delivered dose, in vivo dosimetry is a mandatory procedure for quality assurance. The TLDs feature many advantages such as a small detector size and close tissue equivalence that make them attractive for IOERT as in vivo dosimeters. LiF:Mg,Ti dosimeters (TLD-100) were irradiated with different IOERT electron beam energies (5, 7 and 9 MeV) and with a 6 MV conventional photon beam. For each energy, the TLDs were irradiated in the dose range of 0-10 Gy in step of 2 Gy. Regression analysis was performed to establish the response variation of thermoluminescent signals with dose and energy. The TLD-100 dose-response curves were obtained. In the dose range of 0-10 Gy, the calibration curve was confirmed to be linear for the conventional photon beam. In the same dose region, the quadratic model performs better than the linear model when high dose-per-pulse electron beams were used (F test; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0139287