Elevated Concentrations of Serum Immunoglobulin Free Light Chains in Systemic Lupus Erythematosus Patients in Relation to Disease Activity, Inflammatory Status, B Cell Activity and Epstein-Barr Virus Antibodies

In this study, we examined the concentration of serum immunoglobulin free light chains (FLCs) in systemic lupus erythematosus (SLE) patients and investigated its association with various disease parameters in order to evaluate the role of FLCs as a potential biomarker in SLE. Furthermore, FLCs'...

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Bibliographic Details
Published in:PloS one 2015-09, Vol.10 (9), p.e0138753-e0138753
Main Authors: Draborg, Anette H, Lydolph, Magnus C, Westergaard, Marie, Olesen Larsen, Severin, Nielsen, Christoffer T, Duus, Karen, Jacobsen, Søren, Houen, Gunnar
Format: Article
Language:English
Subjects:
Activation
Adult
Age
Aged
Anti-DNA antibodies
Antibodies
Antibodies, Antinuclear - blood
Antibodies, Viral - blood
Antigens
Arthritis
Autoantibodies - blood
Autoantibodies - immunology
Autoimmune diseases
B-Lymphocytes - immunology
Biomarkers
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Case-Control Studies
Chains
Chronic conditions
Complement component C4
Complement System Proteins - immunology
Consent
Correlation analysis
Development and progression
Epstein-Barr virus
Female
Gene expression
Health aspects
Herpesvirus 4, Human - immunology
Humans
Immunoglobulin A
Immunoglobulin G
Immunoglobulin Light Chains - blood
Immunoglobulins
Infections
Infectious diseases
Inflammation - blood
Inflammation - immunology
Life assessment
Light
Light chains
Lupus
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - virology
Lymphocytes B
Male
Measurement
Middle Aged
Multiple sclerosis
Order parameters
Patients
Physiological aspects
Renal insufficiency
Rheumatology
Studies
Systemic lupus erythematosus
Urine
Viruses
Young Adult
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Summary:In this study, we examined the concentration of serum immunoglobulin free light chains (FLCs) in systemic lupus erythematosus (SLE) patients and investigated its association with various disease parameters in order to evaluate the role of FLCs as a potential biomarker in SLE. Furthermore, FLCs' association with Epstein-Barr virus (EBV) antibodies was examined. Using a nephelometric assay, κFLC and λFLC concentrations were quantified in sera from 45 SLE patients and 40 healthy controls. SLE patients with renal insufficiency were excluded in order to preclude high concentrations of serum FLCs due to decreased clearance. Serum FLC concentrations were significantly elevated in SLE patients compared to healthy controls (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0138753