Renal Function in Chinese HIV-Positive Individuals following Initiation of Antiretroviral Therapy

To identify the prevalence and predictors of abnormal renal function among HIV-positive Chinese patients prior to antiretroviral therapy (ART) initiation and to evaluate subsequent changes in renal function after ART exposure. We conducted a nationwide cohort study of subjects who enrolled in the na...

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Bibliographic Details
Published in:PloS one 2015-08, Vol.10 (8), p.e0135462-e0135462
Main Authors: Zhao, Yan, Zhang, Mingjie, Shi, Cynthia X, Zhang, Yao, Cai, Weiping, Zhao, Qingxia, Li, Yong, Li, Huiqin, Liu, Xia, Chen, Limeng, Ma, Ye, Zhang, Fujie, Liu, Zhongfu, Wu, Zunyou
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Antiretroviral Therapy, Highly Active - adverse effects
China
Cohort Studies
Confidence intervals
Epidermal growth factor receptors
Female
Glomerular filtration rate
Glomerular Filtration Rate - drug effects
Hazard assessment
Hemoglobin
Hepatitis
Hepatitis C
Hepatitis C virus
HIV
HIV Seropositivity - complications
HIV Seropositivity - drug therapy
Human immunodeficiency virus
Humans
Incidence
Lopinavir
Male
Middle Aged
Regression analysis
Regression models
Renal function
Renal Insufficiency - diagnosis
Renal Insufficiency - etiology
Retrospective Studies
Risk analysis
Risk Factors
Ritonavir
Statistical analysis
Systematic review
Tenofovir
Therapy
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Summary:To identify the prevalence and predictors of abnormal renal function among HIV-positive Chinese patients prior to antiretroviral therapy (ART) initiation and to evaluate subsequent changes in renal function after ART exposure. We conducted a nationwide cohort study of subjects who enrolled in the national Chinese ART program from January 1, 2012 to December 31, 2012. We estimated the glomerular filtration rate (eGFR) of subjects prior to and after initiating ART. Risk factors for abnormal renal function, as defined by eGFR
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0135462