Role of Endogenous Opioid System in Ischemic-Induced Late Preconditioning

Opioid receptors (OR) are involved in myocardial late preconditioning (LPC) induced by morphine and δ1-opioid receptor (δ1-OR) agonists. The role of OR in ischemic-induced LPC is unknown. We investigated whether 1) OR are involved in the trigger and/or mediation phase of LPC and 2) a time course eff...

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Bibliographic Details
Published in:	PloS one 2015-07, Vol.10 (7), p.e0134283-e0134283
Main Authors:	Fraessdorf, Jan, Hollmann, Markus W, Hanschmann, Iris, Heinen, André, Weber, Nina C, Preckel, Benedikt, Huhn, Ragnar
Format:	Article
Language:	eng
Subjects:	Anesthesiology Animals Beta endorphin Coronary vessels Dynorphin Endorphins Enkephalin (leucine) Enkephalins Gene expression Heart Heart attacks Hemodynamics Intensive care Intermedin Ischemia Ischemic Preconditioning Laboratory animals Male Mediation Melanocyte stimulating hormone Morphine Naloxone Narcotics Occlusion Opioid peptides Opioid Peptides - blood Opioid Peptides - physiology Opioid receptors Peptides Plasma levels Preconditioning Rats Rats, Wistar Receptors Reperfusion Rodents Signal transduction Veins & arteries
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Summary:	Opioid receptors (OR) are involved in myocardial late preconditioning (LPC) induced by morphine and δ1-opioid receptor (δ1-OR) agonists. The role of OR in ischemic-induced LPC is unknown. We investigated whether 1) OR are involved in the trigger and/or mediation phase of LPC and 2) a time course effect on the expression of different opioid receptors and their endogenous ligands exists. Male Wistar rats were randomly allocated to four groups (each group n = 8). Awake animals were ischemic preconditioned by a 5 minutes coronary occlusion. 24 hours later, anesthetized animals underwent 25 minutes coronary occlusion followed by 2 hours of reperfusion. The role of OR was investigated by treatment with intraperitoneal naloxone (Nal) 10 minutes prior to LPC (Nal-LPC; trigger phase) or 10 min prior to sustained ischemia (LPC-Nal; mediation phase). LPC reduced infarct size from 61±10% in controls to 25±9% (P
ISSN:	1932-6203 1932-6203