Intravenous Tissue Plasminogen Activator Can Be Safely Given without Complete Blood Count Results Back

It is well known that the efficacy of intravenous (i.v.) tissue plasminogen activator (tPA) is time-dependent when used to treat patients with acute ischemic strokes. Our study examines the safety issue of giving IV tPA without complete blood count (CBC) resulted. This is a retrospective observation...

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Bibliographic Details
Published in:PloS one 2015-07, Vol.10 (7), p.e0131234-e0131234
Main Authors: Dong, Yi, Yang, Lumeng, Ren, Jinma, Nair, Deepak S, Parker, Sarah, Jahnel, Jan L, Swanson-Devlin, Teresa G, Beck, Judith M, Mathews, Maureen, McNeil, Clayton J, Ling, Yifeng, Cheng, Xin, Gao, Yuan, Dong, Qiang, Wang, David Z
Format: Article
Language:English
Subjects:
Administration, Intravenous - methods
Aged
Blood
Blood Cell Count - methods
Blood Cells - drug effects
Blood Platelets - drug effects
Blood tests
Brain Ischemia - drug therapy
China
Councils
Demographics
Demography
Female
Health risks
Hemorrhage
Humans
Intervals
Intracranial Hemorrhages - drug therapy
Intravenous administration
Ischemia
Laboratories
Male
Medicine
Neurobiology
Neurological disorders
Neurology
Neurosciences
Patients
Platelet Count - methods
Regression analysis
Retrospective Studies
Risk Factors
Stroke
Stroke - drug therapy
t-Plasminogen activator
Thrombocytopenia
Thrombolytic Therapy - methods
Time Factors
Tissue Plasminogen Activator - administration & dosage
Treatment Outcome
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Summary:It is well known that the efficacy of intravenous (i.v.) tissue plasminogen activator (tPA) is time-dependent when used to treat patients with acute ischemic strokes. Our study examines the safety issue of giving IV tPA without complete blood count (CBC) resulted. This is a retrospective observational study by examining the database from Huashan Hospital in China and OSF/INI Comprehensive Stroke Center in United States. Patient data collected included demographics, occurrence of symptomatic intracranial hemorrhage, door to needle intervals, National Institute of Health Stroke Scale scores on admission, CBC results on admission and follow-up modified Rankin Scale scores. Linear regression and multivariable logistic regression analysis were used to identify factors that would have an impact on door-to-needle intervals. Our study included 120 patients from Huashan Hospital and 123 patients from INI. Among them, 36 in Huashan Hospital and 51 in INI received i.v. tPA prior to their CBC resulted. Normal platelet count was found in 98.8% patients after tPA was given. One patient had thrombocytopenia but no hemorrhagic event. A significantly shorter door to needle interval (DTN) was found in the group without CBC resulted. There was also a difference in treatment interval between the two hospitals. Door to needle intervals had a strong correlation to onset to treatment intervals and NIHSS scores on admission. In patients presented with acute ischemic stroke, the risk of developing hemorrhagic event is low if i.v. tPA is given before CBC has resulted. The door to needle intervals can be significantly reduced.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0131234