Roles of DPY30 in the Proliferation and Motility of Gastric Cancer Cells

Various types of histone methylation have been associated with cancer progression. Depending on the methylation site in histone proteins, its effects on transcription are different. DPY30 is a common member of SET1/MLL histone H3K4 methyltransferase complexes. However, its expression and roles in ga...

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Bibliographic Details
Published in:PloS one 2015-07, Vol.10 (7), p.e0131863-e0131863
Main Authors: Lee, Yong Joo, Han, Myoung-Eun, Baek, Su-Jin, Kim, Seon-Young, Oh, Sae-Ock
Format: Article
Language:English
Subjects:
Cancer
Cell Line, Tumor
Cell Movement - physiology
Cell proliferation
Cell Proliferation - physiology
Chromatin
Cloning
Gastric cancer
Gene expression
Genomics
Humans
Immunohistochemistry
Life sciences
Medical prognosis
Medical research
Methylation
Methyltransferase
Nuclear Proteins - metabolism
Nuclear Proteins - physiology
Penicillin
Phosphorylation
Proteins
Senescence
siRNA
Stem cells
Stomach cancer
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Tissues
Transcription
Tumor cell lines
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Summary:Various types of histone methylation have been associated with cancer progression. Depending on the methylation site in histone proteins, its effects on transcription are different. DPY30 is a common member of SET1/MLL histone H3K4 methyltransferase complexes. However, its expression and roles in gastric cancer have been poorly characterized. To determine whether DPY30 has pathophysiological roles in gastric cancer, its expression and roles were examined. Immunohistochemistry and real time PCR showed up-regulation of DPY30 expression in some gastric cancer cell lines and patients' tissues. Its knockdown by siRNA decreased the proliferation, migration, and invasion of gastric cancer cells, whereas its overexpression showed the opposite effects. These results indicate that DPY30 has critical roles in the proliferation, migration, and invasion of gastric cancer cells, and suggest DPY30 might be a therapeutic target in gastric cancer.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0131863