Blood-borne biomarkers of mortality risk: systematic review of cohort studies

Lifespan and the proportion of older people in the population are increasing, with far reaching consequences for the social, political and economic landscape. Unless accompanied by an increase in health span, increases in age-related diseases will increase the burden on health care resources. Interv...

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Bibliographic Details
Published in:PloS one 2015-06, Vol.10 (6), p.e0127550-e0127550
Main Authors: Barron, Evelyn, Lara, Jose, White, Martin, Mathers, John C
Format: Article
Language:English
Subjects:
Aged
Biocompatibility
Biological markers
Biomarkers
Biomarkers - blood
Biomedical materials
Blood
Brain
Brain natriuretic peptide
C-reactive protein
Cancer
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - mortality
CD40 antigen
Cell adhesion
Cholesterol
Cohort analysis
Cohort Studies
Cortisol
Dehydroepiandrosterone
Diabetes
Erythrocyte sedimentation rate
Erythrocytes
Female
Ferritin
Fibrinogen
Globulins
Health aspects
Health care
Health hazards
Health risks
Health screening
Hemoglobin
Homocysteine
Humans
Intercellular adhesion molecule 1
Interleukin 12
Leukocytes
Leukocytes (granulocytic)
Leukocytes (neutrophilic)
Life span
Ligands
Longevity
Male
MEDLINE
Meta-analysis
Middle Aged
Molecular chains
Monocyte chemoattractant protein 1
Mortality
Neoplasms - blood
Neoplasms - mortality
Nutrition research
Older people
Retirement
Risk assessment
Systematic review
Testosterone
Thyroid
Thyroid gland
Thyroxine
Tissue inhibitor of metalloproteinases
Transferrin
Tumors
United Kingdom
Uric acid
Urokinase
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Summary:Lifespan and the proportion of older people in the population are increasing, with far reaching consequences for the social, political and economic landscape. Unless accompanied by an increase in health span, increases in age-related diseases will increase the burden on health care resources. Intervention studies to enhance healthy ageing need appropriate outcome measures, such as blood-borne biomarkers, which are easily obtainable, cost-effective, and widely accepted. To date there have been no systematic reviews of blood-borne biomarkers of mortality. To conduct a systematic review to identify available blood-borne biomarkers of mortality that can be used to predict healthy ageing post-retirement. Four databases (Medline, Embase, Scopus, Web of Science) were searched. We included prospective cohort studies with a minimum of two years follow up and data available for participants with a mean age of 50 to 75 years at baseline. From a total of 11,555 studies identified in initial searches, 23 fulfilled the inclusion criteria. Fifty-one blood borne biomarkers potentially predictive of mortality risk were identified. In total, 20 biomarkers were associated with mortality risk. Meta-analyses of mortality risk showed significant associations with C-reactive protein (Hazard ratios for all-cause mortality 1.42, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0127550