Factors That Affect Quality of Life among People Living with HIV Attending an Urban Clinic in Uganda: A Cohort Study

With the availability of antiretroviral therapy (ART) and primary general care for people living with HIV (PLHIV) in resource limited settings, PLHIV are living longer, and HIV has been transformed into a chronic illness. People are diagnosed and started on treatment when they are relatively well. A...

Full description

Saved in:

Bibliographic Details
Published in:	PloS one 2015-06, Vol.10 (6), p.e0126810-e0126810
Main Authors:	Mutabazi-Mwesigire, Doris, Katamba, Achilles, Martin, Faith, Seeley, Janet, Wu, Albert W
Format:	Article
Language:	eng
Subjects:	Acquired immune deficiency syndrome Adult AIDS Alcoholic beverages Analysis Anti-Retroviral Agents - administration & dosage Antiretroviral agents Antiretroviral therapy Clinical medicine Demographic aspects Developing countries Drug therapy Education Female Females Gender Health aspects Health sciences Highly active antiretroviral therapy HIV HIV Infections - drug therapy HIV Infections - psychology HIV patients Human immunodeficiency virus Humans Industrialized nations Infections LDCs Male Males Mathematical models Medicine Mental depression Mental disorders Mental health Opportunist infection Patients Prospective Studies Psychological aspects Public health Quality assessment Quality of Life Sexual behavior Sexually transmitted diseases STD Studies Uganda Urban Health Services
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	With the availability of antiretroviral therapy (ART) and primary general care for people living with HIV (PLHIV) in resource limited settings, PLHIV are living longer, and HIV has been transformed into a chronic illness. People are diagnosed and started on treatment when they are relatively well. Although ART results in clinical improvement, the ultimate goal of treatment is full physical functioning and general well-being, with a focus on quality of life rather than clinical outcomes. However, there has been little research on the relationship of specific factors to quality of life in PLHIV. The objective of this study was to investigate factors associated with quality of life among PLHIV in Uganda receiving basic care and those on ART. We enrolled 1274 patients attending an HIV outpatient clinic into a prospective cohort study. Of these, 640 received ART. All were followed up at 3 and 6 months. Health related quality of life was assessed with the MOS-HIV Health Survey and the Global Person Generated Index (GPGI). Multivariate linear regression and logistic regression with generalized estimating equations were used to examine the relationship of social behavioral and disease factors with Physical Health Summary (PHS) score, Mental Health Summary (MHS) score, and GPGI. Among PLHIV receiving basic care, PHS was associated with: sex (p=0.045) - females had lower PHS; age in years at enrollment (p=0.0001) - older patients had lower PHS; and depression (p
ISSN:	1932-6203 1932-6203