Trypanocide treatment of women infected with Trypanosoma cruzi and its effect on preventing congenital Chagas

With the control of the vectorial and transfusional routes of infection with Trypanosoma cruzi, congenital transmission has become an important source of new cases. This study evaluated the efficacy of trypanocidal therapy to prevent congenital Chagas disease and compared the clinical and serologica...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2014-11, Vol.8 (11), p.e3312-e3312
Main Authors: Fabbro, Diana L, Danesi, Emmaria, Olivera, Veronica, Codebó, Maria Olenka, Denner, Susana, Heredia, Cecilia, Streiger, Mirtha, Sosa-Estani, Sergio
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Care and treatment
Chagas Disease - congenital
Chagas Disease - drug therapy
Chagas Disease - immunology
Chagas Disease - prevention & control
Chagas' disease
Child
Child, Preschool
Control
Disease transmission
Female
Genetic disorders
Humans
Infant
Infant, Newborn
Infections
Infectious Disease Transmission, Vertical - prevention & control
Medical research
Medicine and Health Sciences
Mortality
Mothers
Pregnancy
Pregnancy Complications, Parasitic - drug therapy
Pregnancy Complications, Parasitic - immunology
Prevention
Protozoa
Retrospective Studies
Studies
Tropical diseases
Trypanocidal Agents - therapeutic use
Trypanosoma cruzi
Womens health
Young Adult
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Summary:With the control of the vectorial and transfusional routes of infection with Trypanosoma cruzi, congenital transmission has become an important source of new cases. This study evaluated the efficacy of trypanocidal therapy to prevent congenital Chagas disease and compared the clinical and serological evolution between treated and untreated infected mothers. We conducted a multicenter, observational study on a cohort of mothers infected with T. cruzi, with and without trypanocidal treatment before pregnancy. Their children were studied to detect congenital infection. Among 354 "chronically infected mother-biological child" pairs, 132 were treated women and 222 were untreated women. Among the children born to untreated women, we detected 34 infected with T. cruzi (15.3%), whose only antecedent was maternal infection. Among the 132 children of previously treated women, no infection with T. cruzi was found (0.0%) (p
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0003312