A power-law dependence of bacterial invasion on mammalian host receptors

Pathogenic bacteria such as Listeria and Yersinia gain initial entry by binding to host target cells and stimulating their internalization. Bacterial uptake entails successive, increasingly strong associations between receptors on the surface of bacteria and hosts. Even with genetically identical ce...

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Bibliographic Details
Published in:PLoS computational biology 2015-04, Vol.11 (4), p.e1004203-e1004203
Main Authors: Lee, Tae J, Wong, Jeffrey, Bae, Sena, Lee, Anna Jisu, Lopatkin, Allison, Yuan, Fan, You, Lingchong
Format: Article
Language:English
Subjects:
Bacteria
Bacteria - metabolism
Bacteria - pathogenicity
Bacterial Adhesion
Bacterial Infections
Bacterial Proteins - metabolism
Computational Biology
Dependence
E coli
Escherichia coli
Experiments
Flow cytometry
Health aspects
HeLa Cells
Host-bacteria relationships
Host-Pathogen Interactions - physiology
Humans
Identification and classification
Listeria
Mathematical models
Membrane Proteins - metabolism
Models, Biological
Ordinary differential equations
Yersinia
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Summary:Pathogenic bacteria such as Listeria and Yersinia gain initial entry by binding to host target cells and stimulating their internalization. Bacterial uptake entails successive, increasingly strong associations between receptors on the surface of bacteria and hosts. Even with genetically identical cells grown in the same environment, there are vast differences in the number of bacteria entering any given cell. To gain insight into this variability, we examined uptake dynamics of Escherichia coli engineered to express the invasin surface receptor from Yersinia, which enables uptake via mammalian host β1-integrins. Surprisingly, we found that the uptake probability of a single bacterium follows a simple power-law dependence on the concentration of integrins. Furthermore, the value of a power-law parameter depends on the particular host-bacterium pair but not on bacterial concentration. This power-law captures the complex, variable processes underlying bacterial invasion while also enabling differentiation of cell lines.
ISSN:1553-7358
1553-734X
1553-7358
DOI:10.1371/journal.pcbi.1004203