Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure

Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, are lacking. MicroRNAs are short, non-coding strand...

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Bibliographic Details
Published in:PloS one 2015-05, Vol.10 (5), p.e0128076-e0128076
Main Authors: Baker, Luisa A, Lee, Karla C L, Palacios Jimenez, Carolina, Alibhai, Hatim, Chang, Yu-Mei, Leckie, Pamela J, Mookerjee, Rajeshwar P, Davies, Nathan A, Andreola, Fausto, Jalan, Rajiv
Format: Article
Language:English
Subjects:
Acetaminophen
Acetaminophen - adverse effects
Analgesics
Analysis
Animals
Biomarkers
Brain
Brain injury
Catastrophic failure analysis
Chemical and Drug Induced Liver Injury - blood
Coding
Complications and side effects
Creatinine
Damage detection
Damage patterns
Deoxyribonucleic acid
Diagnosis
Disease
Disease Models, Animal
DNA
Dosage and administration
Exosomes
Genetic aspects
Head injuries
Hospitals
Intracranial pressure
Intracranial Pressure - drug effects
Kidneys
Liver
Liver diseases
Liver failure
Liver Failure, Acute - blood
Liver Failure, Acute - chemically induced
Medical prognosis
Medical schools
MicroRNA
MicroRNAs
MicroRNAs - blood
miRNA
Non-coding RNA
Perfusion
Physiological aspects
Plasma
Plasma levels
Pressure
Ribonucleic acid
RNA
Rodents
Science
Studies
Swine
Traumatic brain injury
Veterinary colleges
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Summary:Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, are lacking. MicroRNAs are short, non-coding strands of RNA that are released into the circulation following tissue injury. In this study, we have characterised the release of both global microRNA and specific microRNA species into the plasma using a porcine model of acetaminophen-induced acute liver failure. Pigs were induced to acute liver failure with oral acetaminophen over 19h±2h and death occurred 13h±3h thereafter. Global microRNA concentrations increased 4h prior to acute liver failure in plasma (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0128076