Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume

Structural neuroimaging studies have demonstrated lower regional gray matter volume in adolescents with severe substance and conduct problems. These research studies, including ours, have generally focused on male-only or mixed-sex samples of adolescents with conduct and/or substance problems. Here...

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Bibliographic Details
Published in:PloS one 2015-05, Vol.10 (5), p.e0126368
Main Authors: Dalwani, Manish S, McMahon, Mary Agnes, Mikulich-Gilbertson, Susan K, Young, Susan E, Regner, Michael F, Raymond, Kristen M, McWilliams, Shannon K, Banich, Marie T, Tanabe, Jody L, Crowley, Thomas J, Sakai, Joseph T
Format: Article
Language:English
Subjects:
Addictive behaviors
Adolescent
Adolescents
Alcoholism
Analysis
Antisocial personality disorder
Behavior
Brain
Brain - pathology
Brain mapping
Brain research
Child & adolescent psychiatry
Cocaine
Complications and side effects
Conduct Disorder - pathology
Cortex (cingulate)
Cortex (frontal)
Cortex (somatosensory)
Covariance
Decision Making
Dopamine
Female
Girls
Gray Matter - pathology
Humans
Image Processing, Computer-Assisted
Information processing
Inhibition
Magnetic Resonance Imaging
Medical diagnosis
Medical imaging
Medicine
Mental disorders
Neostriatum
Neural networks
Neuroimaging
Neurology
Neurosciences
Organ Size - physiology
Patients
Physiological aspects
Prefrontal cortex
Problem Behavior
Psychological aspects
Regional analysis
Reinforcement
Researchers
Risk taking
Social behavior
Somatosensory cortex
Statistical analysis
Statistical methods
Substance abuse
Substance-Related Disorders - pathology
Substantia grisea
Teenage girls
Teenagers
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Summary:Structural neuroimaging studies have demonstrated lower regional gray matter volume in adolescents with severe substance and conduct problems. These research studies, including ours, have generally focused on male-only or mixed-sex samples of adolescents with conduct and/or substance problems. Here we compare gray matter volume between female adolescents with severe substance and conduct problems and female healthy controls of similar ages. Female adolescents with severe substance and conduct problems will show significantly less gray matter volume in frontal regions critical to inhibition (i.e. dorsolateral prefrontal cortex and ventrolateral prefrontal cortex), conflict processing (i.e., anterior cingulate), valuation of expected outcomes (i.e., medial orbitofrontal cortex) and the dopamine reward system (i.e. striatum). We conducted whole-brain voxel-based morphometric comparison of structural MR images of 22 patients (14-18 years) with severe substance and conduct problems and 21 controls of similar age using statistical parametric mapping (SPM) and voxel-based morphometric (VBM8) toolbox. We tested group differences in regional gray matter volume with analyses of covariance, adjusting for age and IQ at p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0126368