Prognostic Significance of Combination of Preoperative Platelet Count and Neutrophil-Lymphocyte Ratio (COP-NLR) in Patients with Non-Small Cell Lung Cancer: Based on a Large Cohort Study

The aim of this study was to investigate the prognostic significance of the combination of the preoperative platelet count and neutrophil-lymphocyte ratio (COP-NLR) for predicting postoperative survival of patients undergoing complete resection for non-small cell lung cancer (NSCLC). The preoperativ...

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Bibliographic Details
Published in:PloS one 2015-05, Vol.10 (5), p.e0126496-e0126496
Main Authors: Zhang, Hua, Zhang, Lianmin, Zhu, Kaikai, Shi, Bowen, Yin, Yuesong, Zhu, Jinfang, Yue, Dongsheng, Zhang, Bin, Wang, Changli
Format: Article
Language:English
Subjects:
Angiogenesis
Blood
Blood cell count
Blood platelets
Cancer
Cancer therapies
Carcinoma, Non-Small-Cell Lung - blood
Carcinoma, Non-Small-Cell Lung - pathology
Cell survival
Chemotherapy
Cohort analysis
Colorectal cancer
Cytokines
Disease prevention
Female
Gastric cancer
Hospitals
Humans
Inflammation
Laboratories
Lung cancer
Lung diseases
Lung Neoplasms - blood
Lung Neoplasms - pathology
Lymphocytes
Lymphocytes - cytology
Male
Medical prognosis
Metastasis
Middle Aged
Multivariate analysis
Neutrophils
Neutrophils - cytology
NMR
Non-small cell lung cancer
Non-small cell lung carcinoma
Nuclear magnetic resonance
Patients
Physiological aspects
Platelet Count
Platelets
Prognosis
Radiation therapy
Retrospective Studies
Risk groups
Stomach cancer
Surgery
Vascular endothelial growth factor
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Summary:The aim of this study was to investigate the prognostic significance of the combination of the preoperative platelet count and neutrophil-lymphocyte ratio (COP-NLR) for predicting postoperative survival of patients undergoing complete resection for non-small cell lung cancer (NSCLC). The preoperative COP-NLR was calculated on the basis of data obtained.Patients with both an increased platelet count (>30.0 × 104 mm(-3)) and an elevated NLR (>2.3) were assigned a score of 2, and patients with one or neither were assigned as a score of 1 or 0, respectively. A total of 1238 NSCLC patients were enrolled in this analysis. Multivariate analysis using the 15 clinicolaboratory variables selected by univariate analyses demonstrated that the preoperative COP-NLR was an independent prognostic factor for DFS (HR: 1.834, 95%CI: 1.536 to 2.200, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0126496