Therapeutic Efficacy of Stem Cell-based Therapy in Peripheral Arterial Disease: A Meta-Analysis

Several cell-based therapies for peripheral arterial disease (PAD) have been studied in multiple clinical trials; however, the outcome of this treatment remains controversial. The aim of this study was to perform a meta-analysis of the clinical trials on stem cell-based therapy after PAD. We searche...

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Bibliographic Details
Published in:PloS one 2015-04, Vol.10 (4), p.e0125032-e0125032
Main Authors: Liu, Yumeng, Xu, Yunyun, Fang, Fang, Zhang, Jianting, Guo, Liang, Weng, Zhen
Format: Article
Language:English
Subjects:
Aged
Amputation
Angiogenesis
Ankle
Bias
Bone marrow
Cardiovascular disease
Cell- and Tissue-Based Therapy
Clinical trials
Clinical Trials as Topic
Confidence intervals
Data processing
Diabetes
Granulocytes
Healing
Humans
Ischemia
Laboratories
Medical research
Mesenchymal stem cells
Meta-analysis
Middle Aged
Mortality
Patients
Pediatrics
Peripheral Arterial Disease - pathology
Peripheral Arterial Disease - therapy
Stem Cell Transplantation
Stem cells
Studies
Systematic review
Therapy
Treatment Outcome
Ulcers
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Summary:Several cell-based therapies for peripheral arterial disease (PAD) have been studied in multiple clinical trials; however, the outcome of this treatment remains controversial. The aim of this study was to perform a meta-analysis of the clinical trials on stem cell-based therapy after PAD. We searched for clinical trials that investigated the effect of stem cell-based therapy on patients with PAD and were published between January 2000 and October 2014. The outcomes of interest comprised all-cause mortality, amputation rate, ulcer healing, and ankle-brachial index (ABI). In addition, pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the safety and efficacy of the stem cell-based therapies for PAD. Thirteen studies were retrieved from 261 citations for the analysis, and in total, 527 patients (mean age: 64.2 years; median follow up: 6 months) were included in the analysis. After synthesizing data, the meta-analysis showed significant improvement in the amputation rate (OR=0.33, 95%CI=0.22-0.51; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0125032