Patients with systemic lupus erythematosus have higher prevalence of thyroid autoantibodies: a systematic review and meta-analysis

Thyroid autoimmunity is considered the most common type of organ-specific autoimmune disorder and can be associated with other autoimmune endocrine disorders or non-endocrine diseases. Systemic lupus erythematosus is a prototypical autoimmune disorder with multifactorial etiology. The pathogenesis a...

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Bibliographic Details
Published in:PloS one 2015-04, Vol.10 (4), p.e0123291-e0123291
Main Authors: Pan, Xi-Feng, Gu, Jian-Qiu, Shan, Zhong-Yan
Format: Article
Language:English
Subjects:
Analysis
Antigens
Autoantibodies
Autoantibodies - blood
Autoimmune diseases
Autoimmunity
B cells
Case-Control Studies
Chronic conditions
Confidence intervals
Development and progression
Endocrine disorders
Etiology
Humans
Immunological tolerance
Lupus
Lupus Erythematosus, Systemic - immunology
Medical ethics
Meta-analysis
Pathogenesis
Patients
Prevalence studies (Epidemiology)
Systemic lupus erythematosus
Thyroid
Thyroid Hormones - immunology
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Summary:Thyroid autoimmunity is considered the most common type of organ-specific autoimmune disorder and can be associated with other autoimmune endocrine disorders or non-endocrine diseases. Systemic lupus erythematosus is a prototypical autoimmune disorder with multifactorial etiology. The pathogenesis and development of the disease may result from a loss of immune tolerance and the resulting synthesis of autoantibodies against nuclear antigens. Autoimmune factors may be common features of both thyroid autoimmunity and systemic lupus erythematosus, making it likely that both conditions may coexist within some patients. A number of studies have investigated whether an association between thyroid autoimmunity and systemic lupus erythematosus exists. However, the results of these studies have been inconsistent. Furthermore, most of these studies have had relatively small sample sizes, which have rendered them insufficiently powerful to determine whether there is an association between systemic lupus erythematosus and thyroid autoimmunity. The main objective of this meta-analysis is to provide reliable estimates of the extent of any association between thyroid autoimmunity and systemic lupus erythematosus by combining the primary data from all relevant studies. Literature databases were searched, including the Medline, Embase, Web of Science, Chinese Wanfang and CBM databases, from January 1970 to May 2014. A total of 1076 systemic lupus erythematosus cases and 1661 healthy controls were included in this study. From these data, the odds ratio (OR) and the corresponding 95% confidence interval (95% CI) were calculated. The meta-analysis results showed that the prevalence of thyroid autoantibody positivity in patients with systemic lupus erythematosus was higher than in healthy controls (TgAb: OR = 2.99, 95% CI = 1.83-4.89; TPOAb: OR = 2.20, 95% CI = 1.27-3.82, respectively). The results of this meta-analysis suggest that thyroid autoimmunity is more prevalent in patients with systemic lupus erythematosus than in a control group.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0123291