Frequency-dependent changes in the regional amplitude and synchronization of resting-state functional MRI in stroke

Resting-state functional magnetic resonance imaging (R-fMRI) has been intensively used to assess alterations of inter-regional functional connectivity in patients with stroke, but the regional properties of brain activity in stroke have not yet been fully investigated. Additionally, no study has exa...

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Bibliographic Details
Published in:PloS one 2015-04, Vol.10 (4), p.e0123850-e0123850
Main Authors: Zhu, Jianfang, Jin, Yuanyuan, Wang, Kai, Zhou, Yumiao, Feng, Yue, Yu, Maihong, Jin, Xiaoqing
Format: Article
Language:English
Subjects:
Abnormalities
Acupuncture
Aged
Aged, 80 and over
Amplitudes
Aphasia
Brain
Brain - physiopathology
Brain Ischemia - physiopathology
Brain Mapping
Change detection
Cognitive ability
Connectivity
Cortex (parietal)
Female
Frequencies
Frequency dependence
Functional magnetic resonance imaging
Gender
Homogeneity
Humans
Image Processing, Computer-Assisted
Magnetic resonance
Magnetic Resonance Imaging
Male
Medical imaging
Middle Aged
Neural networks
Neuroimaging
Patients
Properties (attributes)
Regional analysis
Schizophrenia
Stroke
Stroke - physiopathology
Studies
Synchronism
Synchronization
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Summary:Resting-state functional magnetic resonance imaging (R-fMRI) has been intensively used to assess alterations of inter-regional functional connectivity in patients with stroke, but the regional properties of brain activity in stroke have not yet been fully investigated. Additionally, no study has examined a frequency effect on such regional properties in stroke patients, although this effect has been shown to play important roles in both normal brain functioning and functional abnormalities. Here we utilized R-fMRI to measure the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo), two major methods for characterizing the regional properties of R-fMRI, in three different frequency bands (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.73 Hz; and typical band: 0.01-0.1 Hz) in 19 stroke patients and 15 healthy controls. Both the ALFF and ReHo analyses revealed changes in brain activity in a number of brain regions, particularly the parietal cortex, in stroke patients compared with healthy controls. Remarkably, the regions with changed activity as detected by the slow-5 band data were more extensive, and this finding was true for both the ALFF and ReHo analyses. These results not only confirm previous studies showing abnormality in the parietal cortex in patients with stroke, but also suggest that R-fMRI studies of stroke should take frequency effects into account when measuring intrinsic brain activity.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0123850